Targeting dopaminergic neuronal death: Luteolin as a therapeutic modulator in Parkinson’s disease

被引：0

作者：

Shivani Chib ^{[1
]}

Bhaskar Jyoti Dutta ^{[4
]}

Gurjeet Singh ^{[2
]}

Randhir Singh ^{[3
]}

Shamsher Singh ^{[1
]}

机构：

[1] Central University of Punjab,Department of Pharmacology

[2] NIPER,Department of Pharmacology and Toxicology

[3] Chitkara University,Center for Research Impact and Outcome, Chitkara College of Pharmacy

[4] ISF College of Pharmacy,Department of Pharmacology

来源：

3 Biotech | 2025年 / 15卷 / 5期

关键词：

Dopamine; Luteolin; Rotenone; Parkinson’s disease; Dopaminergic neurons;

D O I：

10.1007/s13205-025-04267-9

中图分类号：

学科分类号：

摘要：

Understanding the convoluted roles of dopamine in brain function is supreme for elucidating the pathophysiology and the therapeutic approach of movement disorders. Of which, Parkinson’s disease (PD) is a progressive neurological ailment characterized by disturbed motor and non-motor functions. Luteolin, a plant-derived flavonoid, exhibits neuroprotective properties through its antioxidant and anti-inflammatory effects. In this study, we evaluated the therapeutic potential of luteolin in a rotenone-induced Wistar rat model of PD. Results of behavior assessment showed that luteolin (25 mg/kg and 50 mg/kg i.p.) treatment for 28 days significantly and dose-dependently improved motor functions. Furthermore, biochemical analysis demonstrated that luteolin restored oxidative balance by elevating glutathione (GSH) levels and reducing nitrate content. Additionally, ELISA results indicated that luteolin modulated level of tumor necrosis factor-alpha (TNF-α) and Bax, thereby reducing inflammation and neuronal apoptosis. Moreover, dopamine levels were significantly increased in rat brain homogenate, corroborating the neuroprotective effects of luteolin. Histopathological analysis further confirmed dopaminergic neuronal preservation in the cortex. These findings suggest that luteolin may serve as a potential therapeutic candidate for PD by mitigating oxidative stress, neuroinflammation, and apoptosis.

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