GENETIC POLYMORPHISMS OF INTERLEUKINS IL-1A, IL-1B, AND IL-1RN IN PATIENTS WITH PERIODONTAL DISEASE AND DENTO-MAXILLARY ANOMALIES

被引：0

作者：

Albu, Stefan-Dimitrie ^{[1
]}

Dragomirescu, Anca-Oana ^{[2
]}

Albu, Cristina-Crenguta ^{[3
]}

Suciu, Ioana ^{[4
]}

Ionescu, Ecaterina ^{[2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Dent, Dept Periodontol, Bucharest, Romania

[2] Carol Davila Univ Med & Pharm, Fac Dent, Dept Orthodont & Dentofacial Orthopaed, Bucharest, Romania

[3] Carol Davila Univ Med & Pharm, Fac Dent, Dept Genet, Bucharest, Romania

[4] Carol Davila Univ Med & Pharm, Fac Dent, Dept Endodont, Bucharest, Romania

来源：

ROMANIAN JOURNAL OF ORAL REHABILITATION | 2024年 / 16卷 / 03期

关键词：

periodontal disease; dento-maxillary anomalies; genetic polymorphisms; IL-1A rs1800587; IL-1B rs1143634; IL-1RN rs419598; CYTOKINES; DIAGNOSIS;

D O I：

10.6261/RJOR.2024.3.16.27

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: The study aims to investigate the interaction between genetic polymorphisms of interleukins IL-1A rs1800587, IL-1B rs1143634, and IL-1RN rs419598 and dento-maxillary anomalies (DMAn) in periodontal disease (PD). Methods: Conducted at the "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, this pilot study involved two groups: patients with DMAn and PD, and patients with PD without DMAn. We examined IL-1A rs1800587, IL-1B rs1143634, and IL-1RN rs419598 polymorphisms using microfluidic SNP genotyping. Results: Statistical analysis of genotypes indicated the following: (1) IL1A rs1800587: The C/C genotype also showed significant trends (p=0.057), being more frequently found in PD patients without DMAn (90% vs. 40%); (2) IL-1B rs1143634: Significant trends were found for the C/T genotype (p=0.057), which was more frequently found in patients with PD and DMAn (60% vs. 10%); (3) IL1RN rs419598: The analysis did not show statistically significant differences between the two groups (p=0.332). Statistical analysis of alleles indicated the following: (1) IL-1A rs1800587 and IL-1B rs1143634: Significant trends were found for the T alleles (p=0.057), which were more frequent in patients with PD and DMAn; (2) IL-1RN rs419598: The allele frequency analysis did not indicate statistically significant differences between the two groups (p=1.000). Conclusion: Combined analysis of genotypes and alleles indicates the following: (1) The frequencies of T alleles and C/T genotypes of the IL-1A rs1800587 and IL1B rs1143634 genes were statistically significantly higher in patients with PD and DMAn. (2) The frequencies of C/C genotypes of IL-1A rs1800587 and IL-1B rs1143634 genes were statistically significantly higher in PD patients without DMAn. (3) No statistically significant differences were found between the two groups regarding the frequency of genotypes or alleles of the IL-1RN rs419598 gene.

引用

页码：253 / 266

页数：14

共 50 条

[1] Analysis of the Association of IL-1A, IL-1B, and IL-1RN Genetic Polymorphisms with Peri-implantitis in a Portuguese Population
Cardoso, Jose Maria
Ribeiro, Ana Clara
Proenca, Luis
Noronha, Susana
Alves, Ricardo Castro
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 2024, 39 (04) : e103 - e111
[2] Genetic Polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and Risk of Silicosis in a Chinese Occupational Population
Wu, Fen
Xia, Zhaolin
Qu, Yabin
Tang, Yunxia
Cao, Duozhi
Sun, Pin
Christiani, David C.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 2008, 51 (11) : 843 - 851
[3] Genetic Polymorphism of Interleukin-1A (IL-1A), IL-1B, and IL-1 Receptor Antagonist (IL-1RN) and Prostate Cancer Risk
Xu, Hua
Ding, Qiang
Jiang, Hao-Wen
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (20) : 8741 - 8747
[4] Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis
Cardoso, Jose Maria
Duarte, Sofia
Ribeiro, Ana Clara
Mascarenhas, Paulo
Noronha, Susana
Alves, Ricardo Castro
APPLIED SCIENCES-BASEL, 2022, 12 (14):
[5] Association Between IL-1B and IL-1RN Gene Polymorphisms and Chagas' Disease Development Susceptibility
Cruz-Robles, David
Pablo Chavez-Gonzalez, Juan
Magdalena Cavazos-Quero, Maria
Perez-Mendez, Oscar
Reyes, Pedro A.
Vargas-Alarcon, Gilberto
IMMUNOLOGICAL INVESTIGATIONS, 2009, 38 (3-4) : 231 - 239
[6] Prevalence of IL-1A and IL-1B polymorphisms in a Greek population
Sakellari, D
Koukoudetsos, S
Arsenakis, M
Konstantinidis, A
JOURNAL OF CLINICAL PERIODONTOLOGY, 2003, 30 (01) : 35 - 41
[7] IL-1B and IL-1RN polymorphisms are not associated with increased risk of gastroduodenal diseases in Korean
Yang, US
Lee, JH
Kim, GH
Heo, J
Kang, DH
Song, GA
Cho, M
Jeon, ES
Park, DY
GASTROENTEROLOGY, 2003, 124 (04) : A404 - A404
[8] Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma
Sarani, Hosna
Mollashahi, Behrouz
Taheri, Mohsen
Bahari, Gholamreza
Hashemi, Seyed Mahdi
Hashemi, Mohammad
Ghavami, Saeid
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2021, 40 (07): : 707 - 719
[9] Prevalence of IL-1A and IL-1B polymorphisms in a Greek population.
Sakellari, D
Koukoudetsos, S
Arsenakis, M
Konstantinidis, A
JOURNAL OF DENTAL RESEARCH, 2002, 81 : A122 - A122
[10] Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1α, IL-1β, and IL-1RN) in patients with periodontal disease
Meisel, P
Siegemund, A
Dombrowa, S
Sawaf, H
Fanghaenel, J
Kocher, T
JOURNAL OF PERIODONTOLOGY, 2002, 73 (01) : 27 - 32

← 1 2 3 4 5 →