Background: Quadriceps strength is relevant for recovering functional capacity in total knee arthroplasty (TKA). This requires strength exercises with high loads, which is difficult to perform after TKA. Rehabilitation with blood flow restriction (BFR) produces gains in strength and muscle mass, avoiding the use of heavy loads. Objective: To identify exercise prescription parameters and the effect of BFR training on muscle mass, muscle strength, and functional capacity of patients with TKA. Methods: Following the PRISMA-ScR methodology, a systematic search was carried out in the following databases: Pubmed, Virtual Health Library, Scopus, and Web of Science. The execution of exercises with BFR during TKA prehabilitation and rehabilitation stages were considered. Two authors independently assessed articles for eligibility, and a third author resolved conflicts. Results: 5 articles were selected. During the prehabilitation stage, increases in strength, muscle mass, and functionality occurred. Muscle strength increased in the rehabilitation stage. Studies with a control group did not detect significant differences. Various protocols were applied regarding the prescription, dosage, and implementation of the exercise programs. Conclusion: Strength, muscle size, and physical function increase in people with TKA during the prehabilitation and rehabilitation stages. The analysis carried out indicates a wide methodological variety, lack of standardization, and gaps in BFR protocol application.