Daratumumab plus Bortezomib/Lenalidomide/ Dexamethasone in Patients With Transplant-ineligible or Transplant-deferred Newly Diagnosed Multiple Myeloma: Results of the Phase 3 CEPHEUS Study

被引:0
|
作者
Usmani, Saad Z. [1 ]
Facon, Thierry [2 ]
Hungria, Vania [3 ]
Bahlis, Nizar J. [4 ]
Venner, Christopher P. [5 ,6 ]
Braunstein, Marc [7 ]
Pour, Ludek [8 ]
Marti, Josep [9 ]
Basu, Supratik [10 ,11 ]
Cohen, Yael C. [12 ]
Matsumoto, Morio [13 ]
Suzuki, Kenshi [14 ]
Hulin, Cyrille [15 ]
Grosicki, Sebastian [16 ]
Legiec, Wojciech [17 ]
Beksac, Meral [18 ]
Maiolino, Angelo [19 ]
Liu, Weiping [20 ]
Wang, Jianping [21 ]
Krevvata, Maria [21 ]
Lopez-Masi, Lorena [22 ]
Carey, Jodi [21 ]
Rowe, Melissa [23 ]
Carson, Robin [21 ]
Zweegman, Sonja [24 ]
机构
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[2] Univ Lille, CHU Lille, Serv Malad Sang, Lille, France
[3] Clin Med Sao Germano, Sao Paulo, Brazil
[4] Univ Calgary, Arnie Charbonneau Canc Inst, Calgary, AB, Canada
[5] Univ Alberta, Cross Canc Inst, Dept Med Oncol, Edmonton, AB, Canada
[6] Univ British Columbia, BC Canc Vancouver Ctr, Vancouver, BC, Canada
[7] NYU Langone Hlth, Perlmutter Canc Ctr, New York, NY USA
[8] Univ Hosp Brno, Brno, Czech Republic
[9] Hosp Univ Mutua Terrassa, Terrassa, Spain
[10] Royal Wolverhampton NHS Trust, Wolverhampton, England
[11] Univ Wolverhampton, CRN West Midlands, NIHR, Wolverhampton, England
[12] Tel Aviv Univ, Fac Med & Hlth Sci, Tel Aviv Sourasky Ichilov Med Ctr, Tel Aviv, Israel
[13] Natl Hosp Org, Dept Hematol, Shibukawa Med Ctr, Gunma, Japan
[14] Japanese Red Cross Med Ctr, Dept Hematol, Tokyo, Japan
[15] Univ Hosp, Dept Hematol, Hop Haut Leveque, Pessac, France
[16] Med Univ Silesian, Sch Publ Hlth, Dept Hematol & Canc Prevent, Katowice, Poland
[17] St John Dukla Oncol Ctr Lublin Land, Dept Hematol & Bone Marrow Transplantat, Lublin, Poland
[18] Istinye Univ, Ankara Liv Hosp, Ankara, Turkiye
[19] Inst Amer Ensino Pesquisa & Inovacao, Rio De Janeiro, Brazil
[20] Janssen Res & Dev, Shanghai, Peoples R China
[21] Janssen Res & Dev LLC, Spring House, PA USA
[22] Janssen Res & Dev LLC, Raritan, NJ USA
[23] Janssen Res & Dev LLC, High Wycombe, Bucks, England
[24] Vrije Univ Amsterdam, Dept Hematol, Canc Ctr Amsterdam, Amsterdam UMC, Amsterdam, Netherlands
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
OA-63
引用
收藏
页码:S288 / S289
页数:2
相关论文
共 50 条
  • [1] Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS trial (Feb, 10.1038/s41591-024-03485-7, 2025)
    Usmani, Saad Z.
    Facon, Thierry
    Hungria, Vania
    Bahlis, Nizar J.
    Venner, Christopher P.
    Braunstein, Marc
    Pour, Ludek
    Marti, Josep M.
    Basu, Supratik
    Cohen, Yael C.
    Matsumoto, Morio
    Suzuki, Kenshi
    Hulin, Cyrille
    Grosicki, Sebastian
    Legiec, Wojciech
    Beksac, Meral
    Maiolino, Angelo
    Takamatsu, Hiroyuki
    Perrot, Aurore
    Turgut, Mehmet
    Ahmadi, Tahamtan
    Liu, Weiping
    Wang, Jianping
    Chastain, Katherine
    Vermeulen, Jessica
    Krevvata, Maria
    Lopez-Masi, Lorena
    Carey, Jodi
    Rowe, Melissa
    Carson, Robin
    Zweegman, Sonja
    NATURE MEDICINE, 2025, : 1195 - 1202
  • [2] Daratumumab Plus Lenalidomide and Dexamethasone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Maia Age Subgroup Analysis
    Facon, Thierry
    Kumar, Shaji K.
    Weisel, Katja
    Usmani, Saad
    Moreau, Philippe
    Plesner, Torben
    Orlowski, Robert Z.
    Bahlis, Nizar Jacques
    Basu, Supratik
    Nahi, Hareth
    Hulin, Cyrille
    Quach, Hang
    O'Dwyer, Michael
    Perrot, Aurore
    Venner, Christopher P.
    Raje, Noopur
    Tiab, Mourad
    Macro, Margaret
    Frenzel, Laurent
    Leleu, Xavier
    Pei, Huiling
    Carson, Robin
    Borgsten, Fredrik
    Goldschmidt, Hartmut
    BLOOD, 2022, 140 : 10133 - 10136
  • [3] Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA
    Facon, Thierry
    Cook, Gordon
    Usmani, Saad Z.
    Hulin, Cyrille
    Kumar, Shaji
    Plesner, Torben
    Touzeau, Cyrille
    Bahlis, Nizar J.
    Basu, Supratik
    Nahi, Hareth
    Goldschmidt, Hartmut
    Quach, Hang
    Mohty, Mohamad
    Venner, Christopher P.
    Weisel, Katja
    Raje, Noopur
    Hebraud, Benjamin
    Belhadj-Merzoug, Karim
    Benboubker, Lotfi
    Decaux, Olivier
    Manier, Salomon
    Caillot, Denis
    Ukropec, Jon
    Pei, Huiling
    Van Rampelbergh, Rian
    Uhlar, Clarissa M.
    Kobos, Rachel
    Zweegman, Sonja
    LEUKEMIA, 2022, 36 (04) : 1066 - 1077
  • [4] Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA
    Thierry Facon
    Gordon Cook
    Saad Z. Usmani
    Cyrille Hulin
    Shaji Kumar
    Torben Plesner
    Cyrille Touzeau
    Nizar J. Bahlis
    Supratik Basu
    Hareth Nahi
    Hartmut Goldschmidt
    Hang Quach
    Mohamad Mohty
    Christopher P. Venner
    Katja Weisel
    Noopur Raje
    Benjamin Hebraud
    Karim Belhadj-Merzoug
    Lotfi Benboubker
    Olivier Decaux
    Salomon Manier
    Denis Caillot
    Jon Ukropec
    Huiling Pei
    Rian Van Rampelbergh
    Clarissa M. Uhlar
    Rachel Kobos
    Sonja Zweegman
    Leukemia, 2022, 36 : 1066 - 1077
  • [5] Daratumumab, lenalidomide, and dexamethasone in Japanese patients with transplant-ineligible newly diagnosed multiple myeloma: a phase 1b study
    Takamatsu, Hiroyuki
    Iida, Shinsuke
    Shibayama, Hirohiko
    Shibayama, Kazuhiro
    Yamazaki, Hiroshi
    Suzuki, Kenshi
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2020, 111 (05) : 692 - 701
  • [6] Daratumumab, lenalidomide, and dexamethasone in Japanese patients with transplant-ineligible newly diagnosed multiple myeloma: a phase 1b study
    Hiroyuki Takamatsu
    Shinsuke Iida
    Hirohiko Shibayama 
    Kazuhiro Shibayama
    Hiroshi Yamazaki
    Kenshi Suzuki
    International Journal of Hematology, 2020, 111 : 692 - 701
  • [7] A Phase II Study of Modified Lenalidomide, Bortezomib, and Dexamethasone (RVD lite) for Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma
    O'Donnell, Elizabeth
    Laubach, Jacob P.
    Yee, Andrew J.
    Huff, Carol Ann
    Basile, Frank
    Wade, Philip M.
    Paba-Prada, Claudia E.
    Ghobrial, Irene M.
    Schlossman, Robert L.
    Couture, Nicole
    Doherty, Lauren
    Lyons, Hannah
    English, Caroline
    Munshi, Nikhil
    Anderson, Kenneth C.
    Richardson, Paul G.
    Raje, Noopur
    BLOOD, 2014, 124 (21)
  • [8] Incidence of herpes zoster in transplant-ineligible patients with newly diagnosed multiple myeloma treated with daratumumab, lenalidomide, and dexamethasone
    Horigome, Yuichi
    Kamata, Hirotoshi
    Michishita, Yusuke
    Yokoyama, Maki
    Tadera, Noriyuki
    Hayama, Kei
    Suzuki, Takahiro
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2025,
  • [9] A Phase II Study of Lenalidomide, Ixazomib, Dexamethasone, and Daratumumab in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma (AFT-41)
    O'Donnell, Elizabeth K.
    Suman, Vera Jean
    Geyer, Susan M.
    Nadeem, Omar
    Dinner, Shira
    Yee, Andrew J.
    Laubach, Jacob P.
    Mo, Clifton C.
    Tuchman, Sascha A.
    Donadio, Kristen
    Sinclair, Sarah
    Raje, Noopur S.
    Richardson, Paul G.
    BLOOD, 2021, 138
  • [10] Oral ixazomib, lenalidomide, and dexamethasone for transplant-ineligible patients with newly diagnosed multiple myeloma
    Facon, Thierry
    Venner, Christopher P.
    Bahlis, Nizar J.
    Offner, Fritz
    White, Darrell J.
    Karlin, Lionel
    Benboubker, Lotfi
    Rigaudeau, Sophie
    Rodon, Philippe
    Voog, Eric
    Yoon, Sung-Soo
    Suzuki, Kenshi
    Shibayama, Hirohiko
    Zhang, Xiaoquan
    Twumasi-Ankrah, Philip
    Yung, Godwin
    Rifkin, Robert M.
    Moreau, Philippe
    Lonial, Sagar
    Kumar, Shaji K.
    Richardson, Paul G.
    Rajkumar, S. Vincent
    BLOOD, 2021, 137 (26) : 3616 - 3628