Unveiling the interaction and combined effects of multiple metals/ metalloids exposure to TNF-α and kidney function in adults using bayesian kernel machine regression and quantile-based G-computation

被引：0

作者：

Luo, Kuei-Hau ^{[1
]}

Tu, Hung-Pin ^{[2
]}

Chung, Yong-Chuan ^{[3
,4
]}

Huang, Min-Hsin ^{[3
]}

Yang, Chen-Cheng ^{[1
,5
]}

Chen, Tzu-Hua ^{[6
]}

Yang, Cheng-Hong ^{[7
,8
]}

Chuang, Hung-Yi ^{[1
,9
,10
,11
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Publ Hlth & Environm Med, Kaohsiung 807, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Business Management, Kaohsiung 804, Taiwan

[4] Kaohsiung Municipal Siaogang Hosp, Adm Management Ctr, Kaohsiung 812, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Occupat Med, Kaohsiung 812, Taiwan

[6] Kaohsiung Municipal Tatung Hosp, Dept Family Med, Kaohsiung 801, Taiwan

[7] Tainan Univ Technol, Dept Informat Management, Tainan 71002, Taiwan

[8] Natl Kaohsiung Univ Sci & Technol, Dept Elect Engn, Kaohsiung 80778, Taiwan

[9] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Occupat & Environm Med, Kaohsiung 807, Taiwan

[10] Kaohsiung Med Univ, PhD Program Environm & Occupat Med, Kaohsiung 807, Taiwan

[11] Kaohsiung Med Univ, Coll Med, Res Ctr Precis Environm Med, Kaohsiung 807, Taiwan

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2024年 / 86卷

关键词：

Metals; Mixture; Bayesian Kernel Machine Regression (BKMR); Quantile G -computation; Kidney function; TNF-alpha; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; INFLAMMATORY RESPONSES; HEAVY-METALS; CADMIUM; BLOOD; LEAD; ASSOCIATION; PREVALENCE; APOPTOSIS;

D O I：

10.1016/j.jtemb.2024.127552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Exposure to multiple metals may cause adverse effects, particularly in the kidneys. However, studies on the combined and interaction effects of metal mixtures on human health remain limited. Objective: The study aims to evaluate the interaction between metals and assess the combined effects of exposure to metal mixtures on tumor necrosis factor-alpha (TNF-alpha) levels and kidney function Methods: Particular emphasis has been placed on the impact of various metals, including arsenic (As), cadmium (Cd), lead (Pb), as well as essential trace elements, such as cobalt (Co), copper (Cu), selenium (Se), and zinc (Zn), on human health and their potential collective influence on both TNF-alpha and kidney function. This cross-sectional study analyzed the data of 421 adults who underwent a health examination. Generalized linear model (GLM), Bayesian kernel machine regression (BKMR), and quantile-based G-computation (qgcomp) were used to evaluate the association and joint effects between the metals and TNF-alpha, as well as kidney function. Results: Increased concentrations of As ((3 = 0.11,95% CI = 0.05, 0.17) and Pb ((3 = 0.30, 95% CI = 0.23, 0.37) in the blood were associated with elevated levels of TNF-alpha, while elevated Cu ((3 = -0.42, 95% CI = -0.77, -0.07) levels were linked to a significant reduction in TNF-alpha. The overall effect of metals mixture showed a significant association with a decline in eGFR and an increase TNF-alpha in the BKMR model. Qgcomp analysis of the metals mixture ((3 = -0.06, 95% CI = -0.07, -0.05) indicated that As, Pb, and Zn were the primary contributors to the reduction in eGFR, while As and Pb were the major contributors in metals mixture ((3 = 0.12, 95% CI = 0.08, 0.15) to the elevation of TNF-alpha levels. Conclusion: Exposure to multiple metals could have joint association with the TNF-alpha levels and kidney function. Furthermore, TNF-alpha could act as a mediator between metal mixtures and eGFR.

引用

页数：12