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Giant Cell Granuloma of the Jaws and Keratin-Positive Giant Cell-Rich Tumor of Bone and Soft Tissue
被引:0
|作者:
Coura, Bruna Pizziolo
[1
]
Sant'Ana, Maria Sissa Pereira
[2
]
Fonseca, Felipe Paiva
[2
]
de Sousa, Silvia Ferreira
[2
]
Gomes, Carolina Cavalieri
[1
]
Gomez, Ricardo Santiago
[2
]
机构:
[1] Univ Fed Minas Gerais UFMG, Biol Sci Inst, Dept Pathol, Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais UFMG, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG, Brazil
关键词:
genetics;
giant cell granuloma;
giant cell tumor;
keratin-positive giant cell tumor;
D O I:
10.1111/jop.13587
中图分类号:
R78 [口腔科学];
学科分类号:
1003 ;
摘要:
BackgroundDifferent giant cell-rich tumors may occur in the jaws. Recently, a new condition known as keratin-positive giant-cell rich tumor harboring recurrent HMGA2::NCOR2 fusions has been described. Interestingly, the mononuclear cells of this tumor are immunoreactive with the AE1/AE3 keratin. Considering the similarities of central and peripheral giant cell granuloma of the jaws with the keratin-positive giant cell-rich tumor of the soft tissue and bone, we hypothesized whether the keratin-positive tumors could also occur in the maxillary bones.Methods and ResultsAn immunohistochemical investigation of AE1/AE3 in a cohort of 16 cases of peripheral and central giant cell granuloma of the jaws was carried out. None of the cases was keratin-positive.ConclusionsAlthough no immunopositivity for keratin was observed in the present giant cell granulomas cohort, we cannot completely exclude the possibility of keratin-positive giant cell-rich tumors occurring in the jaws. Therefore, oral pathologists should be aware about this condition and further studies using cohorts from different laboratories are necessary.
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页码:667 / 668
页数:2
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