Nanomedicine in cardiology: Precision drug delivery for enhanced patient outcomes

被引:0
|
作者
Peng, Fengli [1 ]
Wang, Zimu [2 ]
Qiu, Zhimei [1 ]
Zhang, Wei [1 ]
Zhao, Yongchao [1 ]
Li, Chaofu [3 ]
Shi, Bei [1 ]
机构
[1] Zunyi Med Univ, Dept Cardiol, Affiliated Hosp, Zunyi 563000, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai, Peoples R China
[3] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Cardiol,Coll Bioengn, Chongqing, Peoples R China
关键词
Nanocarriers; Nanomedicine; Extracellular vesicles; Targeted delivery; Cardiovascular diseases; SMOOTH-MUSCLE-CELLS; EXTRACELLULAR VESICLES; LDL-CHOLESTEROL; MOUSE MODEL; NANOPARTICLES; GENE; SIRNA; RESTENOSIS; INHIBITION; INFARCT;
D O I
10.1016/j.lfs.2024.123199
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cardiovascular diseases as a primary driver of global morbidity and mortality. Despite the array of therapeutic avenues in clinical practice, predominantly pharmaceutical and surgical interventions, they often fall short of fully addressing the clinical exigencies of cardiovascular patients. In recent years, nanocarriers have shown great potential in the treatment and diagnose of cardiovascular diseases. They can enhance drug targeting and bioavailability while reducing side effects. Additionally, by improving imaging and detection technologies, they enhance early diagnosis and disease monitoring capabilities. These advancements in technology offer new solutions for precision medicine in cardiovascular diseases, advancing treatment efficacy and disease management. Crafted from biomaterials, metals, or their amalgamations, these nanocarriers approximate the dimensions of biologically active molecules like proteins and DNA. Cardiovascular nanomedicine, in its infancy, has only recently burgeoned. Yet, with continual refinement in nanocarrier architecture, drug delivery mechanisms, and therapeutic outcomes, the potential of nanomedical technologies in clinical contexts becomes increasingly evident. This review aims to consolidate the strides made in nanocarrier research concerning the treatment and diagnose of cardiovascular diseases.
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页数:16
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