ABLATION OF XBP1 AND ATF6 UPR-RELATED PATHWAYS INTERFERES WITH MYELINATION AND EXACERBATES DISEASE SEVERITY IN MICE MODELS OF CMT1B

被引：0

作者：

Gentile, Francesco ^{[1
]}

Touvier, Thierry ^{[1
]}

Veneri, Francesca ^{[1
]}

Sorgiati, Noemie ^{[1
]}

D'Aprile, Chiara ^{[1
]}

Morelli, Letizia ^{[1
]}

Claessens, Anke ^{[1
]}

Ferri, Cinzia ^{[1
]}

Valenzano, Serena ^{[2
]}

Del Carro, Ubaldo ^{[2
]}

Kaufman, Randal J. ^{[3
]}

Duong, Phu ^{[4
]}

Wiseman, R. Luke ^{[5
]}

Svaren, John ^{[6
]}

Shy, Michael E. ^{[7
]}

D'Antonio, Maurizio ^{[1
]}

机构：

[1] IRCCS Osped San Raffaele, Div Genet & Cell Biol, Biol Myelin Unit, Milan, Italy

[2] Ist Sci San Raffaele, Div Neurosci, Milan, Italy

[3] Sanford Burnham Prebys Med Discovery Inst, Degenerat Dis Program, La Jolla, CA USA

[4] Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53706 USA

[5] Scripps Res Inst, La Jolla, CA 92037 USA

[6] Univ Wisconsin, Madison, WI USA

[7] Univ Iowa, Iowa City, IA USA

来源：

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM | 2024年 / 29卷

关键词：

CMT; UPR; mice models; XBP1; ATF6;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P 055

引用

页码：S23 / S24

页数：2

共 13 条

[1] ACTIVATION OF THE UPR TRANSCRIPTION FACTORS XBP1 AND ATF6 MODULATES DISEASE SEVERITY IN CMT1B MICE
Touvier, Thierry
Veneri, Francesca
Claessens, Anke
Ferri, Cinzia
Mastrangelo, Rosa
Del Carro, Ubaldo
Barkauskas, Christina
Glimcher, Laurie
Kaufman, Randal J.
Duong, Phu
Svaren, John
Shy, Michael
Wrabetz, Lawrence
D'Antonio, Maurizio
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2022, 27 : S32 - S33
[2] Activation of the ER stress transcription factors XBP1 AND ATF6 modulates disease severity in CMT1B mice
Touvier, Thierry
Veneri, Francesca
Bianchi, Francesca
Wrabetz, Lawrence
Shy, Michael
D'Antonio, Maurizio
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2020, 25 (04) : 473 - 474
[3] Role of the ATF6 branch of the UPR in CMT1B neuropathy
Veneri, Francesca
Ferri, Cinzia
Mastrangelo, Rosa
Bianchi, Francesca
Valenzano, Serena
Del Carro, Ubaldo
Kaufman, Randal J.
D'Antonio, Maurizio
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2021, 26 (03) : 340 - 340
[4] Activation of the Er stress transcription factor Xbp1 modulates disease severity in CMT1B mice
D'Antonio, Maurizio
Touvier, Thierry
Ferri, Cinzia
Mastrangelo, Rosa
Glimcher, Laurie
Wrabetz, Lawrence
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2018, 23 (04) : 256 - 256
[5] Activation of the ER stress transcription factor XBP1 modulates disease severity in CMT1B mice
Touvier, T.
Ferri, C.
Mastrangelo, R.
Barkauskas, C.
Glimcher, L.
Wrabetz, L.
D'Antonio, M.
GLIA, 2019, 67 : E454 - E454
[6] Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells
Sharma, Rohit B.
Darko, Christine
Alonso, Laura C.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (41) : 14164 - 14177
[7] Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR
Scapin, Cristina
Ferri, Cinzia
Pettinato, Emanuela
Bianchi, Francesca
Del Carro, Ubaldo
Feltri, M. Laura
Kaufman, Randal J.
Wrabetz, Lawrence
D'Antonio, Maurizio
JOURNAL OF NEUROSCIENCE, 2020, 40 (42): : 8174 - 8187
[8] Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and sternness by activating PERK signaling
Spaan, Claudia N.
Smit, Wouter L.
de Jeude, Jooske F. van Lidth
Meijer, Bartolomeus J.
Muncan, Vanesa
van den Brink, Gijs R.
Heijmans, Jarom
CELL DEATH & DISEASE, 2019, 10 (7)
[9] Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
Claudia N. Spaan
Wouter L. Smit
Jooske F. van Lidth de Jeude
Bartolomeus J. Meijer
Vanesa Muncan
Gijs R. van den Brink
Jarom Heijmans
Cell Death & Disease, 10
[10] The IRE1/XBP1 pathway of the UPR modulates disease severity in Charcot-Marie-Tooth type 1B mice
D'Antonio, M.
Touvier, T.
Veneri, F. A.
Claessens, A.
Mastrangelo, R.
Ferri, C.
Bianchi, F.
Del Carro, U.
Shy, M.
Wrabetz, L.
GLIA, 2021, 69 : E372 - E373

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