[1] Univ Porto, Fac Med Porto, Dept Biomed, Expt Biol Unit, Porto, Portugal
[2] Univ Porto, Pain Neurobiol, Inst Invest & Inovacao Saude i3S, Porto, Portugal
[3] Univ Porto, IBMC, Porto, Portugal
[4] Univ Fed Santa Maria, Ctr Nat & Exact Sci, Grad Program Biol Sci Toxicol Biochem, Santa Maria, RS, Brazil
[5] Community Univ Chapeco Reg, Grad Program Environm Sci, Chapeco, SC, Brazil