The rapidly increased applications of nanomaterials technologies become of important interest in the field of environmental science and eliminating pollutants from aqueous solutions. The core of the current study was the removal of Co-trimoxazole (CTMZ) by the Nano Emulsion (NE) process from aqueous solutions using green iron Nano oxides/graphene coated slag (INOGS) as a co-stabilizer agent. In the NE phase, xylene serves as the primary solvent, D2EHPA acts as an extractant, INOGS with Span80 functions as a stabilizing agent, and the water phase inside the nanoemulsion is composed of H2SO4 solution. SEM, TEM, and EDS analysis prove successful preparation and coating properties of the INOGS. The research investigated how different factors such as membrane/ internal phase volume ratio, concentration of INOGS and extractant, H2SO4 concentration, and pH of the polluted phase affect the effectiveness of removal and the stability of Nanoemulsion. After 10 min minutes of gentle mixing, over 99 % of CTMZ is removed from the external phase when nanoemulsion and polluted phases are combined, resulting in maximum emulsion stability (about 100 %) without any breakage. This discovery highlights the significance of utilizing nanomaterials to enhance the nanoemulsion process for eliminating contaminants from the environment.