Linking Anxiolytic Action to Hippocampal "Theta"-A Personal History

被引：0
|
作者：
Mcnaughton, N. [1 ]
机构：
[1] Univ Otago, Dept Psychol, Dunedin, New Zealand
来源：
HIPPOCAMPUS | 2025年 / 35卷 / 01期
关键词：
anxiolytics; brain bypass; reticular stimulation; septal stimulation; theta rhythm; DRIVING SEPTAL STIMULATION; RHYTHMICAL SLOW ACTIVITY; ASCENDING NORADRENERGIC BUNDLE; APPROACH-AVOIDANCE CONFLICT; LONG-TERM; NUCLEUS-ACCUMBENS; BEHAVIORAL EXPERIENCE; GAMMA-AMINOBUTYRATE; LATENT INHIBITION; DOPAMINE RELEASE;
D O I：
10.1002/hipo.23653
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This paper provides a personal history of work starting with the discovery that anxiolytic drugs reduce hippocampal theta frequency. It includes parallel work on septal elicitation of theta carried out in Jeffrey Gray's laboratory in Oxford; a statement of my original scientific perspective on the work; and a description of later work in my laboratory in New Zealand confirming the function of theta rhythmicity per se and its mediation of the effects of anxiolytic drugs on behavior. I finish with comments on risk management with such experiments and their use in larger scale theory development.
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页数：13
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