Pd-Catalyzed Skeletal Rearrangement via C(sp3)-C(sp3) Activation to Access α,β-Unsaturated δ/γ-Lactone

被引：0
|
作者：
Manna, Kartic [1 ]
Maji, Suman [1 ]
Sharma, Akhilesh [2 ]
Kumar, Nikunj [2 ]
Gupta, Puneet [2 ,3 ]
Maiti, Debabrata [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Mumbai 400076, India
[2] Indian Inst Technol, Computat Catalysis Ctr, Dept Chem, Roorkee 247667, Uttarakhand, India
[3] Indian Inst Technol, Ctr Sustainable Energy, Roorkee 247667, Uttaranchal, India
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年
关键词：
skeletal rearrangement; dual ligand; non-polar C(<italic>sp</italic>(3))-C(<italic>sp</italic>(3)) activation; atom-economic; DFT studies;
D O I：
10.1002/anie.202423175
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The activation of non-polar aliphatic C-C bonds represents a significant challenge that remains to be addressed in the field of Pd(II) catalysis. In this study, we present a dual ligand approach as a means of addressing this issue. The process entails lactonization of cyclobutane and cyclopropane carboxylic acid via the activation of non-polar C(sp3)-C(sp3) bond despite the high feasibility of both omicron rtho-C(sp2)-H and beta or gamma -C(sp3)-H activation. Density Functional Theory (DFT) calculations were performed to reveal the mechanistic insights and elucidate the role of dual ligands in facilitating this challenging transformation.
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页数：7
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