Role of subpulmonary right ventricle in sudden cardiac death in adults with congenital heart disease

被引：0
|
作者：
Kawada, Satoshi [1 ,2 ]
Chakraborty, Praloy [1 ,2 ]
Kakarla, Jayant [1 ,2 ]
Nanthakumar, Jared [1 ,2 ,4 ]
Mondesert, Blandine [3 ]
Khairy, Paul [3 ]
Nair, Krishnakumar [1 ,2 ]
机构：
[1] Univ Hlth Network Toronto, Toronto Congenital Cardiac Ctr Adults, Peter Munk Cardiac Ctr, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Univ Montreal, Montreal Heart Inst, Adult Congenital Heart Dis Ctr, Dept Med, Montreal, PQ, Canada
[4] McMaster Univ, Michael De Groote Sch Med, Hamilton, ON, Canada
来源：
HEART RHYTHM | 2025年 / 22卷 / 03期
关键词：
Congenital heart disease; Subpulmonary right ventricle; Sudden cardiac death; Ventricular arrhythmia; Electrophysiological remodeling; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; PULMONARY VALVE-REPLACEMENT; FAILING RIGHT VENTRICLE; REPAIRED TETRALOGY; ANATOMICAL ISTHMUSES; FAILURE SECONDARY; K+ CURRENTS; FOLLOW-UP; FALLOT; RESYNCHRONIZATION;
D O I：
10.1016/j.hrthm.2024.08.016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite improved childhood survival of congenital heart disease (CHD) as a result of advances in management, late-onset sudden cardiac death (SCD) from malignant ventricular arrhythmias remains a leading cause of mortality in adults with CHD. Preventing SCD in these patients requires an understanding of the underlying pathophysiological mechanisms. Many CHD patients experience significant hemodynamic stress on the subpulmonary right ventricle (RV), leading to pathologic remodeling. Unlike acquired heart disease in which left ventricular pathology is prevalent, RV pathologies are crucial in the SCD pathogenesis in CHD patients. This review examines the mechanisms and management of SCD related to subpulmonary RV pathologies in CHD patients.
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页数：11
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