Detecting Artificial Intelligence-Generated Versus Human-Written Medical Student Essays: Semirandomized Controlled Study

Background: Large language models, exemplified by ChatGPT, have reached a level of sophistication that makes distinguishing between human- and artificial intelligence (AI)-generated texts increasingly challenging. This has raised concerns in academia, particularly in medicine, where the accuracy and authenticity of written work are paramount. Objective: This semirandomized controlled study aims to examine the ability of 2 blinded expert groups with different levels of content familiarity-medical professionalsand humanities scholars with expertise in textual analysis-to distinguish between longer scientific texts in German written by medical students and those generated by ChatGPT. Additionally, the study sought to analyze the reasoning behind their identification choices, particularly the role of content familiarity and linguistic features. Methods: Between May and August 2023, a total of 35 experts (medical: n=22; humanities: n=13) were each presented with 2 pairs of texts on different medical topics. Each pair had similar content and structure: 1 text was written by a medical student, and the other was generated by ChatGPT (version 3.5, March 2023). Experts were asked to identify the AI-generated text and justify their choice. These justifications were analyzed through a multistage, interdisciplinary qualitative analysis to identify relevant textual features. Before unblinding, experts rated each text on 6 characteristics: linguistic fluency and spelling/grammatical accuracy, scientific quality, logical coherence, expression of knowledge limitations, formulation of future research questions, and citation quality. Univariate tests and multivariate logistic regression analyses were used to examine associations between participants' characteristics, their stated reasons for author identification, and the likelihood of correctly determining a text's authorship. Results: Overall, in 48 out of 69 (70%) decision rounds, participants accurately identified the AI-generated texts, with minimal difference between groups(medical: 31/43, 72%; humanities: 17/26, 65%; odds ratio [OR] 1.37, 95% CI 0.5-3.9). While content errors had little impact on identification accuracy, stylistic features-particularly redundancy (OR 6.90, 95% CI 1.01-47.1), repetition (OR 8.05, 95% CI 1.25-51.7), and thread/coherence(OR 6.62, 95% CI 1.25-35.2)-playedacrucial role in participants' decisions to identify a text as AI-generated. Conclusions: The findings suggest that both medical and humanities experts were able to identify ChatGPT-generated texts in medical contexts, with their decisions largely based on linguistic attributes. The accuracy of identification appears to be independent of experts' familiarity with the text content. As the decision-making process primarily relies on linguistic attributes-such as stylistic features and text coherence-further quasi-experimental studies using texts from other academic disciplines should be conducted to determine whether instructions based on these features can enhance lecturers' ability to distinguish between student-authored and AI-generated work.