The role of obesity in the development of cardiovascular diseases: An overview of human and rodent studies

Basically, obesity occurs when the amount of calories taken into the body is more than the amount spent in the long term. Treatments applied by reducing calorie intake and increasing movement do not always give positive results. This is because the etiological elements of obesity and the relationship between these elements have not been fully revealed. Factors that play a role in the emergence of obesity include limitation of movement, diet, genetic factors, smoking, psychosocial factors and insomnia. There are many common factors in the pathogenesis of obesity and CVD. In order to reduce the harmful effects of obesity, researchers are creating animal feeding protocols, especially rodents, and conducting studies that cannot be done on humans. The aim of this review is to briefly address two important interrelated issues that affect human health and life: the relationship between obesity and cardiovascular diseases. The review will also dicuss why rodent models are used.