A pilot intervention trial to reduce the use of post-procedural antimicrobials after common endourologic surgeries

Objective: Post-procedural antimicrobial prophylaxis is not recommended by professional guidelines but is commonly prescribed. We sought to reduce use of post-procedural antimicrobials after common endoscopic urologic procedures. Design: A before-after, quasi-experimental trial with a baseline (July 2020-June 2022), an implementation (July 2022), and an intervention period (August 2022-July 2023). Setting: Three participating medical centers. Intervention: We assessed the effect of a bundled intervention on excess post-procedural antimicrobial use (ie, antimicrobial use on post-procedural day 1) after three types of endoscopic urologic procedures: ureteroscopy and transurethral resection of bladder tumor or prostate.The intervention consisted of education, local champion(s), and audit-and-feedback of data on the frequency of post-proceduralantimicrobial-prescribing. Results: 1,272 procedures were performed across all 3 sites at baseline compared to 525 during the intervention period; 644 (50.6%) patientsreceived excess post-procedural antimicrobials during the baseline period compared to 216 (41.1%) during the intervention period. There wasno change in the use of post-procedural antimicrobials at sites 1 and 2 between the baseline and intervention periods. At site 3, the odds ofprescribing a post-procedural antimicrobial significantly decreased during the intervention period relative to the baseline time trend (0.09;95% CI 0.02-0.45). There was no significant increase in post-procedural unplanned visits at any of the sites. Conclusions: Implementation of a bundled intervention was associated with reduced post-procedural antimicrobial use at one of three sites,with no increase in complications. These findings demonstrate both the safety and challenge of guideline implementation for optimalperioperative antimicrobial prophylaxis. This trial was registered on clinicaltrials.gov, NCT04196777.