Effect of VX-770, a Cystic Fibrosis Transmembrane Conductance (CFTR) Potentiator, on Bone Phenotypes in ADO2 Mice

被引：0
|
作者：
Alam, Imranul [1 ]
Gerard-ORiley, Rita [1 ]
Acton, Dena [1 ]
Hong, Jung Min [2 ]
Bruzzaniti, Angela [2 ]
Econs, Michael J. [1 ]
机构：
[1] Indiana Univ Sch Med, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Dent, Indianapolis, IN USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2024年 / 39卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
SUN-171
引用
收藏
页码：265 / 265
页数：1
相关论文
共 50 条
  • [1] Pharmacokinetics (PK), Metabolism and Excretion of [14C] VX-770, a Potentiator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), in Healthy Subjects
    Zha, Jiuhong
    Zhang, Jianbo
    Ordonez, Claudia
    JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 51 (09): : 1358 - 1359
  • [2] Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner
    Eckford, Paul D. W.
    Li, Canhui
    Ramjeesingh, Mohabir
    Bear, Christine E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (44) : 36639 - 36649
  • [3] Discovery of VX-770 (Ivacaftor), a CFTR potentiator for the treatment of cystic fibrosis in G551D patients
    Grootenhuis, Peter D. J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [4] IMPROVEMENT IN SWEAT CHLORIDE CONCENTRATION BY THE CFTR POTENTIATOR VX-770 IN SUBJECTS WITH CYSTIC FIBROSIS AND THE G551D-CFTR MUTATION
    Accurso, F.
    Rowe, S. M.
    Durie, P. R.
    Konstan, M. W.
    Dunitz, J.
    Hornick, D.
    Sagel, S. D.
    Boyle, M. P.
    Uluer, A. Z.
    Moss, R. B.
    Donaldson, S.
    Pilewski, J.
    Rubenstein, R. C.
    Aitken, M. L.
    Ramsey, B.
    Freedman, S. D.
    Dong, Q.
    Zha, J.
    Stone, A.
    Olson, E. R.
    Ordonez, C.
    Campbell, P.
    Ashlock, M.
    Clancy, J. P.
    PEDIATRIC PULMONOLOGY, 2009, : 296 - 296
  • [5] Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation
    Accurso, Frank J.
    Rowe, Steven M.
    Clancy, J. P.
    Boyle, Michael P.
    Dunitz, Jordan M.
    Durie, Peter R.
    Sagel, Scott D.
    Hornick, Douglas B.
    Konstan, Michael W.
    Donaldson, Scott H.
    Moss, Richard B.
    Pilewski, Joseph M.
    Rubenstein, Ronald C.
    Uluer, Ahmet Z.
    Aitken, Moira L.
    Freedman, Steven D.
    Rose, Lynn M.
    Mayer-Hamblett, Nicole
    Dong, Qunming
    Zha, Jiuhong
    Stone, Anne J.
    Olson, Eric R.
    Ordonez, Claudia L.
    Campbell, Preston W.
    Ashlock, Melissa A.
    Ramsey, Bonnie W.
    NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (21): : 1991 - 2003
  • [6] Case History: Kalydeco® (VX-770, Ivacaftor), a CFTR Potentiator for the Treatment of Patients with Cystic Fibrosis and the G551D-CFTR Mutation
    Hadida, Sabine
    Van Goor, Frederick
    Dinehart, Kirk
    Looker, Adam R.
    Mueller, Peter
    Grootenhuis, Peter D. J.
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 49, 2014, 49 : 383 - 398
  • [7] Synthesis of 1,2,3-triazole analogs of CFTR potentiator VX-770
    Ody, Britton
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [8] Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809
    Doiron, Jake E.
    Le, Christina A.
    Ody, Britton K.
    Brace, Jonathon B.
    Post, Savannah J.
    Thacker, Nathan L.
    Hill, Harrison M.
    Breton, Gary W.
    Mulder, Matthew J.
    Chang, Sichen
    Bridges, Thomas M.
    Tang, Liping
    Wang, Wei
    Rowe, Steven M.
    Aller, Stephen G.
    Turlington, Mark
    CHEMISTRY-A EUROPEAN JOURNAL, 2019, 25 (14) : 3662 - 3674
  • [9] Functional Defect of Variants in the Adenosine Triphosphate-Binding Sites of ABCB4 and Their Rescue by the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Ivacaftor ( VX-770)
    Delaunay, Jean-Louis
    Bruneau, Alix
    Hoffmann, Brice
    Anne-Marie
    Durand-Schneider
    Barbu, Veronique
    Jacquemin, Emmanuel
    Maurice, Michele
    Housset, Chantal
    Callebaut, Isabelle
    Aiet-Slimane, Tounsia
    HEPATOLOGY, 2017, 65 (02) : 560 - 570
  • [10] OPPOSING EFFECT OF THE VX-770 GATING POTENTIATOR ON THE CORRECTED ΔF508-CFTR FUNCTION AND PROCESSING
    Veit, Guido
    Avramescu, Radu G.
    Perdomo, Doranda
    Phuan, Puay-Wah
    Bagdany, Miklos
    Pirjo, Apaja
    Borot, Florance
    Szollosi, Daniel
    Wu, Yu-Sheng
    Finkbeiner, Walter E.
    Hegedus, Tamas
    Verkman, A. S.
    Lukacs, Gergely L.
    PEDIATRIC PULMONOLOGY, 2014, 49 : 118 - 119
12345