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Aix Marseille Univ, Univ Hosp Federat DHUNE, APHM,INSERM,Inst Neurosci Syst,UMR 1106, Serv Pharmacol Clin & Pharmacovigilance, Marseille, France Aix Marseille Univ, Univ Hosp Federat DHUNE, APHM,INSERM,Inst Neurosci Syst,UMR 1106, Serv Pharmacol Clin & Pharmacovigilance, Marseille, France