CAR-T cell therapy for the treatment of adult high-grade gliomas

被引：0
|
作者：
Park, Sangwoo [1 ,2 ]
Maus, Marcela V. [1 ,2 ]
Choi, Bryan D. [1 ,2 ,3 ]
机构：
[1] Massachusetts Gen Hosp, Canc Ctr, Cellular Immunotherapy Program, Boston, MA 02114 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Brain Tumor Immunotherapy Lab, Dept Neurosurg, Boston, MA 02114 USA
来源：
NPJ PRECISION ONCOLOGY | 2024年 / 8卷 / 01期
关键词：
CHIMERIC ANTIGEN RECEPTORS; BLOOD-BRAIN-BARRIER; TGF-BETA; CANCER REGRESSION; IMMUNE-RESPONSES; NORMAL-TISSUES; TARGET; GLIOBLASTOMA; IMMUNOTHERAPY; ACTIVATION;
D O I：
10.1038/s41698-024-00753-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] CAR-T Therapy for Pediatric High-Grade Gliomas: Peculiarities, Current Investigations and Future Strategies
    Antonucci, Laura
    Canciani, Gabriele
    Mastronuzzi, Angela
    Carai, Andrea
    Del Baldo, Giada
    Del Bufalo, Francesca
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [2] Pixantrone as a bridge to CAR-T treatment in high-grade transformation of follicular lymphoma
    Morris, Joseph
    O'Reilly, Maeve
    Sargent, Jeremy
    Murphy, Philip
    Glavey, Siobhan
    Quinn, John
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2022, 109 (05) : 593 - 594
  • [3] Dendritic Cell Therapy of High-Grade Gliomas
    Van Gool, Stefaan
    Maes, Wim
    Ardon, Hilko
    Verschuere, Tina
    Van Cauter, Sofie
    De Vleeschouwer, Steven
    BRAIN PATHOLOGY, 2009, 19 (04) : 694 - 712
  • [4] Chemotherapy and Target Therapy in the Management of Adult High-Grade Gliomas
    Spinelli, Gian Paolo
    Miele, Evelina
    Lo Russo, Giuseppe
    Miscusi, Massimo
    Codacci-Pisanelli, Giovanni
    Petrozza, Vincenzo
    Papa, Anselmo
    Frati, Luigi
    Della Rocca, Carlo
    Gulino, Alberto
    Tomao, Silverio
    CURRENT CANCER DRUG TARGETS, 2012, 12 (08) : 1016 - 1031
  • [5] Gene therapy trials for the treatment of high-grade gliomas
    Sonabend, Adam M.
    Ulasov, Ilya V.
    Lesniak, Maciej S.
    GENE THERAPY AND MOLECULAR BIOLOGY, 2007, 11A : 79 - 92
  • [6] Adult high-grade malignant gliomas
    Zustovich, Fable
    Lombardi, Giuseppe
    Amirouchene, Nabil
    Pastorelli, Davide
    ONCOLOGY REVIEWS, 2008, 2 (04) : 195 - 198
  • [7] Neonatal Outcomes following 2 Cases of Maternal CAR-T Therapy for High-Grade B-Cell Lymphoma
    O'Reilly, Daniel
    Jones, Charlotte
    Smith, Aisling
    Mackin, David
    Mc Donald, Laura
    Quinn, John
    O'Reilly, Maeve
    Flinn, Aisling M.
    Leahy, Ronan
    Williams, David
    Donnelly, Jennifer
    Corcoran, David
    NEONATOLOGY, 2024,
  • [8] Temozolomide: therapeutic limitations in the treatment of adult high-grade gliomas
    Chamberlain, Marc C.
    EXPERT REVIEW OF NEUROTHERAPEUTICS, 2010, 10 (10) : 1537 - 1544
  • [9] PDGFRα-SPECIFIC CAR T CELL THERAPY OF PEDIATRIC HIGH-GRADE GLIOMA
    Eckholdt, Kathryn
    Mazrimas, Sara
    Hauser, Paul
    Zaky, Wafik
    Najjar, Amer
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A422 - A422
  • [10] CAR-T Cell Therapy
    Ahmad, Aamir
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12)
12345