Gene Therapy and Gene Editing: Current Trends and Future Prospects of Molecular Medicine

被引:0
|
作者
Sen, Aniruddha [1 ]
Singh, Vijay [1 ]
Dwivedi, Shailendra [1 ]
Agrawal, Ruchika [2 ]
Bansal, Akash [1 ]
Shekhar, Shashank [3 ]
Kushwaha, Sudhir Shyam [4 ]
机构
[1] All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
[2] All India Inst Med Sci Gorakhpur, Dept ENT, Gorakhpur 273008, India
[3] All India Inst Med Sci, Dept Radiotherapy, Gorakhpur 273008, Uttar Pradesh, India
[4] All India Inst Med Sci Gorakhpur, Dept Orthopaed, Gorakhpur 273008, India
关键词
Gene therapy; genome editing; CRISPR-Cas9; genetic disorders; personalized medicine; disease management; clinical applications; ethical considerations; genetic modifications; DELIVERY; DISEASE; IMMUNODEFICIENCY; AAV; CRISPR/CAS9; ADENOVIRUS; PROGRESS; SYSTEMS; TALENS; HUMANS;
D O I
10.2174/0115665232347734250211074241
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Gene therapy and genome editing have emerged as transformative approaches in the management of a diverse range of genetic and acquired diseases. This evaluation offers a thorough examination of the present state and prospects of these innovative technologies. Gene therapy is a prospective approach to the treatment and prevention of a variety of conditions, including complex cancers and inherited genetic disorders, which entail the introduction, removal, or modification of genetic material within a patient's cells. Genome editing, particularly through techniques such as CRISPR-Cas9, enables targeted corrections of genetic defects and opens new possibilities for personalized medicine by allowing for precise modifications at the DNA level. The review addresses the ethical implications, clinical applications, and significant advancements of these technologies. This article endeavors to underscore the substantial influence of gene therapy and genome editing on contemporary medicine by assessing the most recent research and clinical trials, thereby emphasizing their potential to revolutionize disease treatment and management.
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页数:14
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