Five new bisabolane-type sesquiterpenoids with oxygen-containing heterocyclic systems from Curcuma longa

被引：0
|
作者：
Dai, Ou [1 ,2 ]
Wu, Guang-Xu [1 ]
Shu, Hong-Zhen [1 ]
Peng, Cheng [1 ]
Liu, Fei [1 ]
Xiong, Liang [1 ,3 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Hosp Chengdu Univ Tradit Chinese Med, Chengdu 611137, Sichuan, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Sch Med Technol, Chengdu 611137, Peoples R China
来源：
FITOTERAPIA | 2025年 / 181卷
基金：
中国国家自然科学基金;
关键词：
Curcuma longa; Sesquiterpenoids; Bisabolane-type; Vasorelaxant activity; CHEMICAL-CONSTITUENTS; RHIZOMES; EXTRACT;
D O I：
10.1016/j.fitote.2025.106399
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new bisabolane-type sesquiterpenoids (1-5) were isolated from the rhizomes of Curcuma longa, and all of them were oxygen-containing heterocyclic compounds. The structures of the compounds were elucidated using comprehensive spectroscopic techniques, and their absolute configurations were confirmed through electronic circular dichroism (ECD) calculations. All of the compounds were evaluated for their vasorelaxant and antiinflammatory activities. The results showed that only compound 4 exhibited a vasorelaxant effect against KClinduced contraction of rat aortic rings, and it achieved a diastolic ratio that exceeded 25 % at a concentration of 25 mu M.
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页数：7
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