Antioxidants against oxidative stress induced by sodium fluoride toxicity in murine models: A systematic review

被引:0
|
作者
Ortiz-Barroso, Gladys [1 ]
Ramirez-Orozco, Ricardo E. [2 ]
Esparza-Villalpando, Vicente [3 ]
Macedo-Mendoza, Mayra [2 ]
Barrios-Garcia, Tonatiuh [2 ]
Pulido-Hornedo, Nayeli Amalinalli [4 ]
机构
[1] Autonomous Univ Aguascalientes, Hlth Sci Ctr, Av Univ 940, Aguascalientes 20100, Ags, Mexico
[2] Autonomous Univ Aguascalientes, Hlth Sci Ctr, Nutr Dept, Av Univ 940, Aguascalientes 20100, Ags, Mexico
[3] Autonomous Univ Aguascalientes, Hlth Sci Ctr, Dent Dept, Av Univ 940, Aguascalientes 20100, Ags, Mexico
[4] Autonomous Univ Aguascalientes, Basic Sci Ctr, Dept Morphol Histol & Embryol Lab, Av Univ 940, Aguascalientes 20100, Ags, Mexico
关键词
Fluoride; Fluorosis; Oxidative stress; Antioxidant; Treatment; GALLIC ACID; PELTIPHYLLUM-PELTATUM; METHYL-3-O-METHYL GALLATE; MEDIATED CARDIOTOXICITY; PROTECTIVE ROLE; CAFFEIC ACID; RAT; QUERCETIN; DAMAGE; CURCUMIN;
D O I
10.1016/j.jtemb.2025.127619
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Introduction: Fluorosis, a condition resulting from excessive fluoride intake, leads to dental, skeletal, and soft tissue alterations through mechanisms that induce oxidative stress. With its potential to significantly impact the field, this review aims to assess the efficacy of antioxidant agents in murine models exhibiting fluorosis-induced toxicity. By transferring electrons to oxidizing agents, antioxidants can attenuate oxidation reactions and mitigate cellular damage. Methodology: This systematic review adheres to the Preferred Reporting Items for Systematic Reviews and Meta- Analyses guidelines, encompassing articles investigating the impact of antioxidant substances on murine fluorosis models, explicitly focusing on oxidative stress markers and antioxidant levels across various tissues. Results: A qualitative synthesis of 79 articles highlights antioxidant agents such as vitamin C, vitamin E, selenium, carotenoids, polyphenolic compounds (including flavonoids and polyphenolic acids), amino acids, and others among animals with fluorosis induction showed variations in oxidative stress markers and antioxidant activity levels under different administration protocols compared to those receiving prophylactic, concomitant concurrent, or therapeutic antioxidant treatments. Conclusion: Fluoride administration across diverse doses and durations elicits heightened oxidative stress markers in multiple rodent tissues. The current evidence suggests that some antioxidants are effective as a prophylactic and concurrent in murine models of fluorosis. However, the methodological differences between studies prevent the establishment of a protocol for potential standardized use.
引用
收藏
页数:17
相关论文
共 50 条
  • [1] Fluoride-induced oxidative stress of osteoblasts and protective effects of baicalein against fluoride toxicity
    Xiang-Qun Jin
    Hui Xu
    Hong-yan Shi
    Jing-min Zhang
    Han-qi Zhang
    Biological Trace Element Research, 2007, 116 : 81 - 89
  • [2] Fluoride-induced oxidative stress of osteoblasts and protective effects of baicalein against fluoride toxicity
    Jin, Xiang-qun
    Xu, Hui
    Shi, Hong-yan
    Zhang, Jing-min
    Zhang, Han-qi
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2007, 116 (01) : 81 - 89
  • [3] Hexavalent-Chromium-Induced Oxidative Stress and the Protective Role of Antioxidants against Cellular Toxicity
    Singh, Veer
    Singh, Nidhi
    Verma, Manisha
    Kamal, Rashmi
    Tiwari, Ritesh
    Chivate, Mahesh Sanjay
    Rai, Sachchida Nand
    Kumar, Ashish
    Singh, Anupama
    Singh, Mohan P.
    Vamanu, Emanuel
    Mishra, Vishal
    ANTIOXIDANTS, 2022, 11 (12)
  • [4] Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
    Nabavi, Seyed M.
    Nabavi, Seyed F.
    Moghaddam, Akbar H.
    Setzer, William N.
    Mirzaei, Morteza
    ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2012, 84 (04): : 1121 - 1126
  • [5] Fluoride toxicity and oxidative stress
    Reddy, GB
    FLUORIDE, 2004, 37 (01) : 43 - 44
  • [6] ANTIOXIDANTS IN THE MANAGEMENT OF FLUORIDE INDUCED NEURAL OXIDATIVE STRESS IN DEVELOPING RATS
    Basha, Mahaboob P.
    Begum, Shabana
    Madhusudhan, N.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (01): : 201 - 206
  • [7] Testicular toxicity in sodium fluoride treated rats: association with oxidative stress
    Ghosh, D
    Das, S
    Maiti, R
    Jana, D
    Das, UB
    REPRODUCTIVE TOXICOLOGY, 2002, 16 (04) : 385 - 390
  • [8] THE PROTECTIVE EFFECT OF CURCUMIN AGAINST SODIUM FLUORIDE-INDUCED OXIDATIVE STRESS IN RAT HEART
    Nabavi, S. F.
    Nabavi, S. M.
    Ebrahimzadeh, M. A.
    Eslami, Sh.
    Jafari, N.
    Hajizadeh Moghaddam, Akbar
    ARCHIVES OF BIOLOGICAL SCIENCES, 2011, 63 (03) : 563 - 569
  • [9] Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart
    Nabavi, Seyed Fazel
    Nabavi, Seyed Mohammad
    Mirzaei, Morteza
    Hajizadeh Moghaddam, Akbar
    FOOD & FUNCTION, 2012, 3 (04) : 437 - 441
  • [10] Terminalia arjuna Protects Mouse Hearts Against Sodium Fluoride-Induced Oxidative Stress
    Sinha, Mahua
    Manna, Prasenjit
    Sil, Parames C.
    JOURNAL OF MEDICINAL FOOD, 2008, 11 (04) : 733 - 740