Dumbbell-shaped thrombectomy device for cerebral venous sinus thrombus removal with controllable axial and longitudinal maneuverability

被引：1

作者：

Li, Ming ^{[1
,2
]}

Song, Baoying ^{[3
]}

Wu, Yan ^{[1
,2
,3
]}

Zhang, Yang ^{[1
,2
,3
,4
]}

Cao, Xiaofeng ^{[5
]}

Zhang, Hongkang ^{[5
]}

Xu, Yi ^{[1
,2
,3
]}

Wu, Chuanjie ^{[1
,2
,3
]}

Li, Chuanhui ^{[3
]}

Zhou, Chen ^{[4
]}

Liu, Lu ^{[3
]}

Yan, Feng ^{[3
]}

Li, Sijie ^{[1
,2
]}

Chen, Jian ^{[3
]}

Meng, Ran ^{[3
]}

Duan, Jiangang ^{[3
]}

Wu, Di ^{[1
,2
]}

Zuo, Lin ^{[6
]}

Xu, Zikai ^{[7
]}

Li, Zhou ^{[8
,9
]}

Zheng, Yufeng ^{[5
]}

Jiang, Miaowen ^{[4
]}

Ji, Xunming ^{[1
,2
,3
,4
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Beijing Inst Geriatr, Beijing 100053, Peoples R China

[3] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg & Neurosci, Beijing 100053, Peoples R China

[4] Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China

[5] Peking Univ, Sch Mat Sci & Engn, Beijing 100871, Peoples R China

[6] Beihang Univ, Sch Bioengn, Beijing 100191, Peoples R China

[7] Univ Glasgow, Sch Life Sci, Glasgow G12, Scotland

[8] Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing Inst Nanoenergy & Nanosyst, Beijing Key Lab Micronano Energy & Sensor, Beijing 100083, Peoples R China

[9] Tsinghua Univ, Tsinghua Changgung Hosp, Sch Clin Med, Sch Biomed Engn Tsinghua Med, Beijing 100084, Peoples R China

来源：

NATIONAL SCIENCE REVIEW | 2025年 / 12卷 / 03期

基金：

中国国家自然科学基金;

关键词：

NiTi stent retriever; biomechanical compatibility; cerebral venous sinus thrombosis; thrombus removal; ACUTE ISCHEMIC-STROKE; MECHANICAL THROMBECTOMY; VEIN;

D O I：

10.1093/nsr/nwaf015

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cerebral venous sinus thrombosis (CVST) is frequently observed in younger adults and features in large thrombus volume. Due to the triangular-like cross-sectional shape and large diameter of the superior sagittal sinus, all the commercially available artery stent retrievers are not suitable for venous vessels. In this study, a dumbbell-like stent was designed and fabricated by 3D braided technology using NiTi wires; it was manually rotatable and stretchable with controlled length/diameter ratios (2.6-14.0) and reciprocating maneuverability. Computational modeling and an in vitro study were conducted to evaluate the mechanical properties of this device and its ability to trap and remove thrombi from occluded venous vessels was verified by using a swine model. A single-center retrospective clinical study of 10 patients using the Venus-TD to treat patients with CVST was also conducted. Pre/postoperative thrombus volume in 10 patients was quantitatively analysed (12 855.3 +/- 6417.1 vs. 2373.1 +/- 2759.0 mm(3), P < 0.001) with a high recanalization rate, yielding favorable clinical outcomes. This study offers a novel treatment option for patients with extensive CVST.

引用

页数：13

共 3 条

[1] Successful treatment of cerebral venous sinus thrombosis with the Solitaire FR thrombectomy device
Froehler, Michael T.
JOURNAL OF NEUROINTERVENTIONAL SURGERY, 2013, 5 (06) : E45 - +
[2] Dumbbell-shaped middle cranial fossa meningloma with interdural cavernous sinus extension: report of two cases with complete removal
Jung, Tae-Young
Jung, Shin
Jin, Shu-Guang
Jin, Yong-Hao
Kim, In-Young
Kang, Sam-Suk
Kim, Soo-Han
SURGICAL NEUROLOGY, 2006, 66 (03): : 315 - 320
[3] Cerebral venous sinus air embolism following removal of intracranial pressure monitoring device: About an exceptional and fatal complication
Gey, L.
Mingaud, H.
Sahuc, P.
Esnault, P.
Dagain, A.
Joubert, C.
NEUROCHIRURGIE, 2022, 68 (02) : 249 - 251

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