Traditional uses, phytochemical constituents, pharmacological properties, and quality control of Pseudostellaria heterophylla (Miq.) Pax

Ethnopharmacologic relevance: Pseudostellaria heterophylla (Miq.) Pax belongs to the Caryophyllaceae family, which is widely used in traditional Chinese medicine in Asia. P. heterophylla was first documented in the classical text Bencao Congxin, also known as "Haier Shen". As a renowned folk medicine with a long history of medicinal application in China, this plant is frequently employed to address spleen deficiency and fatigue, loss of appetite, and weakness after illness. In recent years, P. heterophylla has gained significant global attention as an important medicinal plant, attributable to its pharmacological activities on the immune and endocrine systems, as well as its diverse applications. Aim of the work: This review aims to deliver a comprehensive and analytical overview of the ethnopharmacology, phytochemistry, pharmacology, pharmacokinetics, toxicology, and quality control of P. heterophylla, while also offering novel insights and opportunities for future research. Materials and methods: Relevant information regarding P. heterophylla was gathered from various databases, including Web of Science, PubMed, ACS Publications, Google Scholar, Baidu Scholar, and CNKI, in addition to The Catalogue of Life, the Flora of China database, and The World Flora Online. All published articles in multiple languages have been included and properly cited. The chemical structure of the compound was illustrated utilizing ChemDraw 19.0 software. Results: P. heterophylla has been traditionally employed to address a range of ailments, including cancer, cardiovascular diseases, diabetes, and respiratory disorders. More than 289 active constituents have been identified in P. heterophylla, comprising cyclic peptides, polysaccharides, saponins, alkaloids, flavonoids, nucleosides, and amino acids. Pharmacological investigations have demonstrated that P. heterophylla and its active constituents exhibit a broad spectrum of biological activities, including anti-cancer, immunomodulatory, antioxidant, hypoglycemic, anti-inflammatory effects, modulation of intestinal flora, enhancement of cognitive function, and inhibition of tyrosine kinase activity. Furthermore, it is extensively utilized in the functional food and cosmetics industries. Conclusion: As a dual-purpose resource for both food and medicine, P. heterophylla possesses significant health care functions and considerable edible and medicinal value, with promising prospects for future development and utilization. However, numerous investigations into the biological activities of P. heterophylla are primarily focused on its extracts and bioactive constituents, and the mechanisms underlying the actions of these extracts and components remain unclear, with a dearth of studies on clinical efficacy and safety. Consequently, further detailed in vitro and in vivo studies investigating the mechanisms of action of pure active compounds of P. heterophylla are warranted, along with additional clinical investigations to ascertain the safety and efficacy of the plant for human use.