Nivolumab-induced Thrombotic Thrombocytopenic Purpura in Patients with Gastric Tube Cancer

被引：0
|
作者：
Yoshida, Yuya [1 ]
Toriyabe, Sakura [1 ]
Imai, Hiroo [1 ]
Sasaki, Keiju [1 ]
Kasahara, Yuki [1 ]
Ouchi, Kota [1 ]
Saijo, Ken [1 ]
Onodera, Koichi [2 ]
Ishioka, Chikashi [1 ]
机构：
[1] Tohoku Univ Hosp, Dept Med Oncol, Sendai, Japan
[2] Tohoku Univ Hosp, Dept Hematol, Sendai, Japan
来源：
INTERNAL MEDICINE | 2024年 / 63卷 / 19期
关键词：
thrombotic thrombocytopenic purpura; gastric tube cancer; hematological adverse events; nivolumab; immunotherapy-related adverse events; immune checkpoint inhibitor; ADVERSE EVENT; HEMOLYTIC-ANEMIA; CLINICAL-TRIALS; CASE SERIES;
D O I：
10.2169/internalmedicine.2931-23
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recently, immune checkpoint inhibitors (ICIs) have been used to treat several cancer types. ICIs have been reported to cause a wide variety of immune-related adverse events, including endocrine, neurologic, gastrointestinal, and cutaneous disorders. Thrombotic thrombocytopenic purpura (TTP) is an autoimmune hematologic disorder characterized by the presence of autoantibodies against a disintegrin and metalloprotease with thrombospondin-1, member 13. Several previous cases of TTP were thought to have been caused by ICI treatment. We herein report a rare case of TTP that developed after long-term treatment with an ICI (nivolumab) for gastric tube cancer.
引用
收藏
页码：2667 / 2671
页数：5
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