AhR governs lipid metabolism: the role of gut microbiota

被引：0
|
作者：
Zheng, Wanru [1 ]
Liu, Mengkuan [1 ]
Lv, Xinyu [1 ]
He, Cuimei [1 ]
Yin, Jie [2 ]
Ma, Jie [1 ]
机构：
[1] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China
[2] Hunan Agr Univ, Coll Anim Sci, Changsha, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2025年 / 16卷
关键词：
aryl hydrocarbon receptor; gut microbiota; lipid metabolism; inflammation; metabolic disease; ARYL-HYDROCARBON RECEPTOR; DIETARY AMINO-ACIDS; HEPATIC STEATOSIS; FATTY LIVER; OBESITY; INHIBITION; PROTECTS; MICE; DIFFERENTIATION; ACCUMULATION;
D O I：
10.3389/fmicb.2025.1442282
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates in regulating the body's immune response, cell proliferation, and apoptosis among a series of processes. Recent studies have revealed a close connection between AhR and lipid metabolism. The gut microbiota plays a significant role in regulating host lipid metabolism. Growing evidence suggests an inseparable link between gut microbiota and AhR signaling. This review summarizes the relationship between AhR and lipid metabolism disorders, as well as the interaction between gut microbiota and AhR, exploring how this interaction modulates host lipid metabolism.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Role of gut microbiota in the control of energy and carbohydrate metabolism
    Venema, Koen
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2010, 13 (04): : 432 - 438
  • [32] Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
    Shulzhenko, Natalia
    Morgun, Andrey
    Hsiao, William
    Battle, Michele
    Yao, Michael
    Gavrilova, Oksana
    Orandle, Marlene
    Mayer, Lloyd
    Macpherson, Andrew J.
    McCoy, Kathy D.
    Fraser-Liggett, Claire
    Matzinger, Polly
    NATURE MEDICINE, 2011, 17 (12) : 1585 - U97
  • [33] Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
    Natalia Shulzhenko
    Andrey Morgun
    William Hsiao
    Michele Battle
    Michael Yao
    Oksana Gavrilova
    Marlene Orandle
    Lloyd Mayer
    Andrew J Macpherson
    Kathy D McCoy
    Claire Fraser-Liggett
    Polly Matzinger
    Nature Medicine, 2011, 17 : 1585 - 1593
  • [34] Effects of Thyroid Powder on Tadpole (Lithobates catesbeiana) Metamorphosis and Growth: The Role of Lipid Metabolism and Gut Microbiota
    Zhu, Bo
    Shao, Chuang
    Xu, Wenjie
    Dai, Jihong
    Fu, Guihong
    Hu, Yi
    ANIMALS, 2024, 14 (02):
  • [35] Gut Microbiota Regulation of AHR Signaling in Liver Disease
    Wang, Baohong
    Zhou, Ziyuan
    Li, Lanjuan
    BIOMOLECULES, 2022, 12 (09)
  • [36] Edible fungi polysaccharides modulate gut microbiota and lipid metabolism: A review
    Xu, Huanyi
    Xue, Zhixiang
    Wang, Pengyi
    Lee, Quancen
    Chen, Zihui
    Liu, Bin
    Liu, Xiaoyan
    Zeng, Feng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 283
  • [37] Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
    Mao, Kairui
    Baptista, Antonio P.
    Tamoutounour, Samira
    Zhuang, Lenan
    Bouladoux, Nicolas
    Martins, Andrew J.
    Huang, Yuefeng
    Gerner, Michael Y.
    Belkaid, Yasmine
    Germain, Ronald N.
    NATURE, 2018, 554 (7691) : 255 - +
  • [38] Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice
    Chen, Jian-Jun
    Xie, Jing
    Zeng, Ben-Hua
    Li, Wen-Wen
    Bai, Shun-jie
    Zhou, Chanjun
    Chen, Wei
    Wei, Hong
    Xie, Peng
    NEUROLOGICAL RESEARCH, 2019, 41 (12) : 1104 - 1112
  • [39] Disruption of gut microbiota alters intestinal lipid metabolism and worsens atherosclerosis
    Kappel, B.
    Stohr, R.
    De Angelis, L.
    Menghini, R.
    Marx, N.
    Federici, M.
    EUROPEAN HEART JOURNAL, 2016, 37 : 790 - 790
  • [40] Can longer lifespan be associated with gut microbiota involvement in lipid metabolism?
    Sardzikova, Sara
    Gajewska, Marta
    Galka, Norbert
    Stefanek, Matus
    Balaz, Andrej
    Garaiova, Martina
    Holic, Roman
    Swiderek, Wieslaw
    Soltys, Katarina
    FEMS MICROBIOLOGY ECOLOGY, 2024, 100 (11)
12345