Minute Ventilation/Carbon Dioxide Production Slope Could Predict Short- and Long-Term Prognosis of Patients After Acute Decompensated Heart Failure

被引:0
|
作者
Tuan, Sheng-Hui [1 ,2 ,3 ]
Huang, I-Ching [4 ,5 ]
Huang, Wei-Chun [6 ,7 ]
Chen, Guan-Bo [8 ]
Sun, Shu-Fen [7 ,9 ]
Lin, Ko-Long [3 ,4 ,10 ]
机构
[1] Natl Cheng Kung Univ, Inst Allied Hlth Sci, Coll Med, Tainan 701, Taiwan
[2] Minist Hlth & Welf, Cishan Hosp, Dept Rehabil Med, Kaohsiung 842, Taiwan
[3] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Phys Med & Rehabil, Kaohsiung 807, Taiwan
[4] Kaohsiung Med Univ Hosp, Dept Phys Med & Rehabil, Kaohsiung 807, Taiwan
[5] Kaohsiung Municipal Tatung Hosp, Dept Phys Med & Rehabil, Kaohsiung 801, Taiwan
[6] Kaohsiung Vet Gen Hosp, Cardiol Ctr, Dept Crit Care Med, Kaohsiung 813, Taiwan
[7] Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei Campus, Taipei 112, Taiwan
[8] Kaohsiung Armed Forces Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Kaohsiung 802, Taiwan
[9] Kaohsiung Vet Gen Hosp, Dept Phys Med & Rehabil, Kaohsiung 813, Taiwan
[10] Kaohsiung Municipal Siaogang Hosp, Dept Phys Med & Rehabil, Kaohsiung 812, Taiwan
来源
LIFE-BASEL | 2024年 / 14卷 / 11期
关键词
cardiopulmonary exercise testing; heart failure; oxygen uptake efficiency slope; phase I cardiac rehabilitation; VE/VCO2; slope; PRESERVED EJECTION FRACTION; VE/VCO2; SLOPE; EXERCISE; EFFICIENCY; CAPACITY; OUTCOMES; INDEX;
D O I
10.3390/life14111429
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
(1) Background: Heart failure (HF) leads to functional disability and major cardiovascular events (MACEs). Cardiopulmonary exercise testing (CPET) is the gold standard for assessing aerobic capacity and prognostic stratification. This study aimed to evaluate the predischarge CPET variables in patients with acute decompensated HF and identify the submaximal CPET variables with prognostic value. (2) Methods: A retrospective cohort study was conducted at a tertiary center in Taiwan. Patients surviving their first episode of decompensated HF and undergoing predischarge CPET (February 2017 to January 2023) were analyzed. Follow-up was conducted until a MACE or administrative censoring (up to 5 years). Cox regression identified the significant predictors of MACE. (3) Results: The study included 553, 485, and 267 patients at the 3-month, 1-year, and 5-year follow-ups, respectively. MACE rates were 15.0%, 34.2%, and 50.9%. The VE/VCO2 slope was a significant predictor of MACE at all intervals. A VE/VCO2 slope >38.95 increased the risk of MACE by 2.49-fold at 3 months and 1.81-fold at 1 year (both p < 0.001). A slope > 37.35 increased the 5-year MACE risk by 1.75-fold (p = 0.002). (4) Conclusions: The VE/VCO2 slope is a significant submaximal CPET predictor of MACE in patients post-acute decompensated HF for both short- and long-term outcomes.
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页数:17
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