TSLP and TSLPr Expression and Localization in the Airways of COPD and Non-COPD Patients

被引：0
|
作者：
Cherif, Lynda Saber [1 ]
Devilliers, Maeva A. [1 ]
Perotin, Jeanne-Marie [1 ,2 ]
Ancel, Julien [1 ,2 ]
Vivien, Alexandre [2 ]
Bonnomet, Arnaud [1 ,3 ]
Delepine, Gonzague [1 ,4 ]
Durlach, Anne [1 ,5 ]
Polette, Myriam [1 ,5 ]
Deslee, Gaetan [1 ,2 ]
Dormoy, Valerian [1 ]
机构：
[1] Univ Reims, Reims, France
[2] CHU Reims, Serv Malad Resp, Reims, France
[3] URCATech, Plateforme Imagerie Cellulaire & Tissulaire PICT, Reims, France
[4] CHU Reims, Hop Maison Blanche, Dept Chirurg Thorac, Reims, France
[5] CHU Reims, Serv Pathol Oncogenet, Reims, France
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2025年 / 55卷 / 01期
关键词：
airways; alarmin; COPD; inflammation; TSLP; THYMIC STROMAL LYMPHOPOIETIN; MECHANISMS; CYTOKINES; RELEASE; ASTHMA;
D O I：
10.1002/eji.202451480
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine activated by allergens, pathogens, and air pollutants. Recent studies suggest TSLP dysregulation in chronic inflammatory diseases. It was highlighted as a key player in the context of asthma-associated mucosal immunity. This study investigated the production and localization of TSLP and its receptors in airway epithelial cells and the related inflammatory response in chronic obstructive pulmonary disease (COPD) and non-COPD patients. TSLP transcripts and proteins were detected in epithelial cells but were not abundant at a steady state. The secretion of airway inflammatory mediators was altered in COPD in association with TSLP production. The cellular and molecular characterization of TSLP signaling may identify COPD patients that could benefit from anti-alarmin therapeutic approaches.
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页数：7
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