Bioinspired Total Synthesis of Polycyclic Natural Products

被引：0
|
作者：
Ishikawa, Hayato [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, 1-8-1 Inohana,Chuo Ku, Chiba 2608675, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2025年 / 73卷 / 02期
关键词：
total synthesis; indole alkaloid; iridoid glycoside; bioinspired reaction; collective synthesis; ALKALOIDS; STRICTOSIDINE; DERIVATIVES; SYNTHASE;
D O I：
10.1248/cpb.c24-00843
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Despite the great strides in biopharmaceuticals and monoclonal antibodies today, natural products remain highly attractive as drug candidates. Therefore, building a library of natural products through total synthesis is critically important for drug discovery. This perspective article details the collective total synthesis of polycyclic natural products using "bioinspired reactions" that mimic natural product biosynthesis. It discusses the total syntheses of 20 natural products, including dimeric diketopiperazine alkaloids, monoterpenoid indole alkaloids, and iridoid glycosides, each achieved in fewer than 14 steps starting from commercially available materials.
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页码：67 / 77
页数：11
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