Synthesis and Anticancer Studies of Pt(II) Complex Derived From 4-Phenylthiosemicarbazone

被引：0

作者：

Gai, Shuangshuang ^{[1
]}

Meng, Lili ^{[2
]}

Qin, Yiming ^{[2
]}

Jiang, Ming ^{[2
]}

机构：

[1] Guangxi Minzu Univ, Inst Hist & Culture Sci & Technol, Nanning, Guangxi, Peoples R China

[2] Guangxi Sci & Technol Normal Univ, Sch Biol & Food Engn, Laibin, Guangxi, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2025年

关键词：

anticancer; apoptosis; autophagy; Pt(II) complex; DOUBLE-STRAND BREAKS; CISPLATIN RESISTANCE; GENOMIC INSTABILITY; DNA-DAMAGE; THIOSEMICARBAZONES; DERIVATIVES; METASTASIS; COPPER(II); ACTIVATION; INHIBITOR;

D O I：

10.1002/cbdv.202402972

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although cisplatin is widely used as a first-line chemotherapy agent, it has significant side effects. Herein, we synthesized a Pt(II) complex (Pt1) derived from o-vanillin-4-phenylthiosemicarbazone ligand and confirmed its crystal structure by x-ray crystallography. Complex Pt1 exhibited potent anticancer activity against various tested cancer cell lines, with particular efficacy against HepG-2 cells. Further investigations revealed that Pt1 inhibited the growth of HepG-2 cells through multiple mechanisms, including the generation of excessive reactive oxygen species (ROS), induction of DNA damage, enhancement of mitochondrial membrane permeability, promotion of apoptosis, and activation of autophagic cell death.

引用

页数：9

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