A slime-inspired phycocyanin/κ-carrageenan-based hydrogel bandage with ultra-stretchability, self-healing, antioxidative, and antibacterial activity for wound healing

Hydrogels have attracted extensive attention as wound dressing owing to their excellent multifunctionality, flexibility, and biocompatibility. Due to the frequent movement and stretching of skin as well as complex surface of wound, traditional wound dressings have difficulty to adapt to motion and irregular wounds. Furthermore, excessive reactive oxygen species (ROS) and bacterial infection can induce delayed wound healing. To this end, we developed a set of versatile phycocyanin-based dual network hydrogels (PPC hydrogels) with polyvinyl alcohol (PVA) and kappa-carrageenan (CRG) as substrate via forming of borate ester bonds, hydrogen bonds, and electrostatic interaction. The PPC hydrogels not only possessed adaptivity, ultra-stretchability (7036.12 %), efficient self-healing and injectability, but also possessed antioxidative and antibacterial capacities conferred by C-phycocyanin (PC) and rhein. Moreover, the hydrogels also exhibited excellent hemostatic ability and high biocompatibility. More remarkably, the PPC-I hydrogel could accelerate wound healing by effect of antiinflammation (downregulating TNF-alpha and IL-6) and promoting collagen deposition and angiogenesis (upregulating CD31), which may be utilized as hydrogel bandages and applied to motion and irregular wounds, thereby promising the application prospect of the hydrogels as wound dressing.