Bioactive secondary metabolites from Talaromyces rugulosus GIZ45-A37 and their anti-inflammatory activity

被引：0
|
作者：
Long, Hailin [1 ]
Liu, Mengzhen [1 ,2 ]
Guan, Shanyue [3 ]
Huang, Xiaoting [1 ]
Rao, Zhongchen [1 ]
Cao, Li [1 ]
Han, Richou [1 ]
机构：
[1] Guangdong Acad Sci, Inst Zool, Guangdong Key Lab Anim Conservat & Resource Utiliz, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangzhou, Peoples R China
[2] South China Normal Univ, Inst Insect Sci & Technol, Sch Life Sci, Guangdong Prov Key Lab Insect Dev Biol & Appl Tech, Guangzhou, Peoples R China
[3] Sun Yat Sen Univ, Instrumental Anal & Res Ctr, Guangzhou, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年
基金：
中国国家自然科学基金;
关键词：
<italic>Talaromyces rugulosus</italic>; entomophagous fungi; macrolide; anti-inflammatory;
D O I：
10.1080/14786419.2024.2446710
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
As part of our plan to discover new bioactive ingredients from entomophagous fungi, a new macrolide compound, talarolide (1), and a new bioactive natural product, talarenal (2), with two known compounds, WF-3681 methy ester (3) and aspergillumarin A (4) were isolated from an insect derived strain Talaromyces rugulosus GIZ45-A37. The structures were determined based on extensive comprehensive spectroscopic (NMR and HR-ESI-MS) analyses and compared with literature values. The relative configuration of 1 was defined by DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods. Compounds 1 and 2 showed inhibitory effect on IL-6 production at 10 and 20 mu M in LPS-stimulated beas-2b cells, indicating their potential anti-inflammatory activity.
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页数：6
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