Moss-produced human complement factor H (CPV-104) for clinical use as regulator of unbalanced complement in complement mediated diseases

被引：0
|
作者：
Tschongov, Todor [1 ]
Konwar, Swagata [1 ]
Haffner, Karsten [1 ]
Hector, Mandy [2 ,3 ,4 ]
Wolf, Anne [2 ,3 ,4 ]
Langmann, Thomas [2 ,3 ,4 ]
Busch, Andreas [5 ]
Schaaf, Andreas [5 ]
Dabrowska-Schlepp, Paulina [5 ]
机构：
[1] Univ Freiburg, Fac Med, Med Ctr, Dept Internal Med Nephrol 4, Freiburg, Germany
[2] Univ Cologne, Fac Med, Dept Ophthalmol, Lab Expt Immunol Eye, Cologne, Germany
[3] Univ Hosp Cologne, Cologne, Germany
[4] Univ Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany
[5] Eleva GmbH, Freiburg, Germany
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2024年 / 54卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P 17
引用
收藏
页码：70 / 70
页数：1
相关论文
共 49 条
  • [1] Moss-Produced Human Factor H (CPV-104): Pioneering Rebalancing Therapies for Kidney Complement Disorders
    Tschongov, Todor Alexandrov
    Konwar, Swagata
    Dabrowska-Schlepp, Paulina
    Busch, Andreas
    Schaaf, Andreas
    Haeffner, Karsten
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
  • [2] CPV-104, an improved recombinant variant of human complement factor H produced in moss, is a prime candidate for clinical application in complement mediated diseases
    Tschongov, Todor
    Konwar, Swagata
    Kleindienst, Jessika
    Dabrowska-Schlepp, Paulina
    Busch, Andreas
    Haeffner, Karsten
    IMMUNOBIOLOGY, 2023, 228 (05) : 78 - 79
  • [3] Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders
    Michelfelder, Stefan
    Parsons, Juliana
    Bohlender, Lennard L.
    Hoernstein, Sebastian N. W.
    Niederkrueger, Holger
    Busch, Andreas
    Krieghoff, Nicola
    Koch, Jonas
    Fode, Benjamin
    Schaaf, Andreas
    Frischmuth, Thomas
    Pohl, Martin
    Zipfe, Peter F.
    Reski, Ralf
    Decker, Eva L.
    Haeffner, Karsten
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (05): : 1462 - 1474
  • [4] Recombinant human complement factor H CPV-101 and CPV-104 dampen microglia reactivity and attenuate light induced retinal degeneration
    Wolf, Anne
    Hector, Mandy
    Behnke, Verena
    Dabrowska-Schlepp, Paulina
    Busch, Andreas
    Schaaf, Andreas
    Langmann, Thomas
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
  • [5] Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity
    Tschongov, Todor
    Konwar, Swagata
    Busch, Andreas
    Sievert, Christian
    Hartmann, Andrea
    Noris, Marina
    Gastoldi, Sara
    Aiello, Sistiana
    Schaaf, Andreas
    Panse, Jens
    Zipfel, Peter F.
    Dabrowska-Schlepp, Paulina
    Haeffner, Karsten
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [6] Mechanism of complement regulator Factor H mediated pneumococcal uptake by human cells
    Agarwal, Vaibhav
    Asmat, Tauseef
    Luo, Shanshan
    Zipfel, Peter F.
    Hammerschmidt, Sven
    MOLECULAR IMMUNOLOGY, 2010, 47 (13) : 2242 - 2242
  • [7] Factor H Autoantibodies and Complement-Mediated Diseases
    Zhang, Yuzhou
    Ghiringhelli Borsa, Nicolo
    Shao, Dingwu
    Dopler, Arthur
    Jones, Michael B.
    Meyer, Nicole C.
    Pitcher, Gabriella R.
    Taylor, Amanda O.
    Nester, Carla M.
    Schmidt, Christoph Q.
    Smith, Richard J. H.
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [8] Binding of human complement regulator factor H by Streptococcus pneumoniae
    Kunert, A
    Hälbich, S
    Hammerschmidt, S
    Zipfel, PF
    MOLECULAR IMMUNOLOGY, 2006, 43 (1-2) : 134 - 135
  • [9] Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera
    Pouw, Richard B.
    Brouwer, Mieke C.
    de Gast, Marlon
    van Beek, Anna E.
    van den Heuvel, Lambertus P.
    Schmidt, Christoph Q.
    van der Ende, Arie
    Sanchez-Corral, Pilar
    Kuijpers, Taco W.
    Wouters, Diana
    BLOOD ADVANCES, 2019, 3 (04) : 621 - 632
  • [10] Factor H family proteins: on complement, microbes and human diseases
    Zipfel, PF
    Skerka, C
    Hellwage, J
    Jokiranta, ST
    Meri, S
    Brade, V
    Kraiczy, P
    Noris, M
    Remuzzi, G
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 : 971 - 978
12345