The coupling problem of thermal and mechanical motion in the process of droplet forming has been analyzed, a mathematical model for droplet forming has been established, and the interaction law between material weight, shape, and droplet temperature obtained. By analyzing the influence of droplet shape, weight, and temperature on the quality of deep-sea glass hemispheres through experiments, the required droplet parameters for forming deep-sea glass hemispheres have been obtained. By using exponential simulation to simulate the cooling rate of glass droplets in the mold, the optimal wall thickness and mold material of the mold have been determined, reducing the forming defects of the glass hemisphere and improving its quality. The actual process situation through the heat conduction inside the glass hemisphere and between the hemisphere and the mold have been simulated, the distribution of glass temperature and stress fields during the molding of the glass hemisphere has been calculated, the layout of the cooling system adjusted, and the process conditions optimized, based on the calculation results, thus improving the quality of the glass hemisphere. Combined with actual experimental results, the above three influencing factors have been demonstrated, and, finally, simulation was used to guide actual production, obtaining a reliable deep-sea glass hemisphere.