The primary cilia: Orchestrating cranial neural crest cell development

被引：1

作者：

Yamaguchi, Hiroyuki ^{[1
]}

Meyer, Matthew D. ^{[2
]}

Barrell, William B. ^{[3
]}

Faisal, Maryam ^{[1
,4
]}

Berdeaux, Rebecca ^{[5
,6
]}

Liu, Karen J. ^{[3
]}

Komatsu, Yoshihiro ^{[1
,7
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, McGovern Med Sch, Houston, TX 77030 USA

[2] Rice Univ, Shared Equipment Author, Houston, TX USA

[3] Kings Coll London, Ctr Craniofacial & Regenerat Biol, London SE1 9RT, England

[4] Rice Univ, George R Brown Sch Engn, Dept Bioengn, Houston, TX 77005 USA

[5] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Integrat Biol & Pharmacol, Houston, TX USA

[6] CellChorus Inc, Houston, TX USA

[7] Univ Texas MD Anderson Canc Ctr, UTHlth Grad Sch Biomed Sci, Grad Program Genet & Epigenet, Houston, TX 77030 USA

来源：

DIFFERENTIATION | 2025年 / 142卷

关键词：

Cilia; Ciliogenesis; Cranial neural crest cells; Craniofacial development; Signal transduction; MECKEL-GRUBER-SYNDROME; JOUBERT-SYNDROME; INTRAFLAGELLAR TRANSPORT; MOTHER CENTRIOLE; SYNDROME GENE; PRIMARY CILIOGENESIS; MUTATIONS CAUSE; MOUSE MODELS; EARLY STEPS; PROTEINS;

D O I：

10.1016/j.diff.2024.100818

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

引用

页数：10

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