Non-invasive fibrosis markers are useful in predicting the presence of varices in compensated cirrhosis and variceal bleeding in decompensated cirrhosis

被引:0
|
作者
Oral, Hakan [1 ]
Ozturk, Bengi [2 ]
Kav, Taylan [2 ]
Keskin, Onur [2 ]
机构
[1] Hacettepe Univ, Dept Internal Med, Sch Med, Ankara, Turkiye
[2] Hacettepe Univ, Dept Internal Med, Div Gastroenterol, Sch Med, Ankara, Turkiye
关键词
non-invasive fibrosis markers; varice prediction; variceal bleeding; cirrhosis; BAVENO VI CRITERIA; LIVER FIBROSIS; ESOPHAGEAL-VARICES; CLINICAL-OUTCOMES; HEPATIC-FIBROSIS; ACCURATE MARKER; SCORE; RISK; ASSOCIATION; PROGRESSION;
D O I
10.1007/s11739-024-03788-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aims to investigate the effectiveness of non-invasive fibrosis markers in predicting varices in compensated advanced chronic liver disease patients and variceal bleeding in decompensated cirrhotic patients. Between 1 July 2020-2021, 137 newly diagnosed cirrhosis patients (67 females/70 males; mean age: 53.35) were included in the study. The diagnosis of cirrhosis was made based on clinical, laboratory, imaging, and, if available, biopsy findings. Laboratory and clinical parameters, including lysyl oxidase-like protein 2 (LOXL2), were recorded for all patients. Commonly used noninvasive fibrosis scores were calculated, and endoscopies were performed to assess varices. All patients were followed up for 12 months, and variceal bleeding events were recorded. Parameters that could predict the presence of varices and variceal bleeding were identified using appropriate statistical methods. Out of the 137 cirrhotic patients, 55 were in the compensated stage and 82 were in the decompensated stage. Varices were detected in 36 (65%) of the compensated cirrhotic patients. It was found that a variceal score derived from spleen size and the ELF score could be used to predict varices (AUC: 0.83). Variceal bleeding developed in 26 (31%) of the patients with decompensated cirrhosis. It was determined that a scoring system derived from albumin, spleen size, LOXL2 level, and the Lok index could be used to predict variceal bleeding in this patient group (AUC: 0.845). This study demonstrates that, besides device-dependent examinations, non-invasive fibrosis scores and various serum parameters can predict varices and variceal bleeding in cirrhotic patients.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] NON-INVASIVE MARKERS TO ESOPHAGEAL VARICES IN COMPENSATED LIVER CIRRHOSIS
    Arhip, Oana
    Cijevschi-Prelipcean, Cristina
    Manole, Alina
    Merchez, Mihaela
    MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2011, 115 (01): : 64 - 69
  • [2] Non-Invasive Markers for Predicting Large Oesophageal Varices in Liver Cirrhosis
    Pai, C. Ganesh
    Kanhangad, Madhava Pai
    Suvarna, Deepak
    Bhat, Ganesh
    Vs, Binu
    GASTROINTESTINAL ENDOSCOPY, 2012, 75 (04) : 469 - 469
  • [3] Evaluation of Non-invasive Fibrosis Markers in Predicting Esophageal Variceal Bleeding
    Cifci, Sami
    Ekmen, Nergiz
    CLINICAL ENDOSCOPY, 2021, 54 (06) : 857 - 863
  • [4] EVALUATION OF NON-INVASIVE TOOLS IN PREDICTING OESOPHAGEAL VARICES IN COMPENSATED LIVER CIRRHOSIS PATIENTS
    Kwape, Lawrence L.
    Abdelsalem, Ahmad A.
    Rose, Penelope
    Parker, Mohammed
    Moolla, Muhammad S.
    Parker, Arifa
    Van Rensburg, Christoffel
    Fredericks, Ernst
    GASTROENTEROLOGY, 2024, 166 (05) : S767 - S768
  • [5] Invasive and non-invasive techniques for detecting portal hypertension and predicting variceal bleeding in cirrhosis: A review
    Zardi, Enrico Maria
    Di Matteo, Francesco Maria
    Pacella, Claudio Maurizio
    Sanyal, Arun J.
    ANNALS OF MEDICINE, 2014, 46 (01) : 8 - 17
  • [6] Role of non-invasive markers in prediction of esophageal varices and variceal bleeding in patients of alcoholic liver cirrhosis from central India
    Kothari, Harit Goverdhan
    Gupta, Sudhir Jagdishoprasad
    Gaikwad, Nitin Rangrao
    Sankalecha, Tushar Hiralal
    Samarth, Amol Rajendra
    TURKISH JOURNAL OF GASTROENTEROLOGY, 2019, 30 (12): : 1036 - 1043
  • [7] Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers
    Du, Yang-Chun
    Jiang, Dan
    Wu, Ji
    RISK MANAGEMENT AND HEALTHCARE POLICY, 2023, 16 : 1555 - 1566
  • [8] NON-INVASIVE STRATIFICATION OF PATIENTS WITH COMPENSATED CIRRHOSIS AND NO GASTROESOPHAGEAL VARICES (GEV)
    Zenlea, Talia
    Garcia-Tsao, Guadalupe
    Groszmann, Roberto J.
    Grace, Norman D.
    Burroughs, Andrew K.
    Bosch, Jaime
    HEPATOLOGY, 2010, 52 (04) : 1068A - 1068A
  • [9] Platelet count/spleen diameter ratio for non-invasive diagnosis of oesophageal varices: Is it useful in compensated cirrhosis?
    Mangone, Manuela
    Moretti, Alessandra
    Alivernini, Federica
    Papi, Claudio
    Orefice, Ruggero
    Dezi, Angelo
    Amadei, Emanuela
    Aratari, Annalisa
    Bianchi, Marco
    Tornatore, Valentina
    Koch, Maurizio
    DIGESTIVE AND LIVER DISEASE, 2012, 44 (06) : 504 - 507
  • [10] CIRRHOSIS: NON-INVASIVE PARAMETERS FOR PREDICTING THE OCCURRENCE OF OOESOPHAGEAL VARICES
    Sujatha, S. M.
    Vasumathi, G.
    Kumar, P. Sampath
    Ramalingam, A.
    Chander, P. Kishore
    Valarmathi, K.
    JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS, 2016, 5 (40): : 2560 - 2565