Therapeutic Effect of Lactiplantibacillus plantarun HFY11 Isolated from Naturally Fermented Yak Yogurt on Lincomycin Hydrochloride-Induced Diarrhea in Mice

被引：1

作者：

Tan, Fang ^{[1
]}

Ren, Lixuan ^{[1
]}

Kong, Chang-Suk ^{[1
,2
,3
]}

机构：

[1] Silla Univ, Dept Biosci, Busan 46958, South Korea

[2] Silla Univ, Dept Food & Nutr, Busan 46958, South Korea

[3] Silla Univ, Marine Biotechnol Ctr Pharmaceut & Foods, Busan 46958, South Korea

来源：

MICROORGANISMS | 2024年 / 12卷 / 11期

关键词：

Lactiplantibacillus plantarun; diarrhea; lincomycin hydrochloride; mice; expression; COLONIC-MUCOSA; PROBIOTICS; COLITIS;

D O I：

10.3390/microorganisms12112307

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study aimed to observe the therapeutic effect of Lactiplantibacillus plantarun HFY11 (LP-HFY11) on lincomycin hydrochloride-induced diarrhea in mice. The results showed that LP-HFY11 alleviated weight loss and intestinal and colon tissue lesions caused by diarrhea. The serum assay showed that LP-HFY11 decreased interleukin 17A (IL-17A), IL-6, 5-hydroxytryptamine, and malondialdehyde levels and increased total antioxidant capacity in mice with diarrhea. LP-HFY11 also downregulated the mRNA expression of cystic fibrosis transmembrane conductance regulator (CFTR), epidermal growth factor receptor (EGFR), and transforming growth factor beta 1 (TGF beta 1) and upregulated the expression of recombinant sodium/hydrogen exchanger 1 (NHE1) and NHE4 in the colon tissues of mice with diarrhea. In conclusion, the study showed that LP-HFY11 could effectively inhibit diarrhea, and the effect was better than that of the drug Bifidobacterium tetragenous viable bacteria tablets (Bifidobacterium-TVBT).

引用

页数：13

共 8 条

[1] Inhibitory Effect of Lactiplantibacillus plantarun HFY11 on Compound Diphenoxylate-Induced Constipation in Mice
Tan, Fang
Kong, Chang-Suk
BIOMOLECULES, 2025, 15 (03)
[2] Interventional Effects of Lactobacillus plantarum Hfy04 Isolated from Naturally Fermented Yak Yogurt on Oxazolone-Induced Colitis in BALB/c Mice
Zheng, Haitao
Ping, Xiaoli
Wu, Ruizi
Lei, Cen
Mao, Huijia
Pan, Yanni
He, Yongpeng
Zhao, Xin
INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2024, 20 (05) : 817 - 824
[3] Antifungal Effect of Metabolites from a New Strain Lactiplantibacillus Plantarum LPP703 Isolated from Naturally Fermented Yak Yogurt
Peng, Qian
Yang, Jing
Wang, Qiang
Suo, Huayi
Hamdy, Ahmed Mahmoud
Song, Jiajia
FOODS, 2023, 12 (01)
[4] Isolation and Identification of Lactobacillus plantarum HFY05 from Natural Fermented Yak Yogurt and Its Effect on Alcoholic Liver Injury in Mice
Yi, Ruokun
Tan, Fang
Liao, Wei
Wang, Qiang
Mu, Jianfei
Zhou, Xianrong
Yang, Zhennai
Zhao, Xin
MICROORGANISMS, 2019, 7 (11)
[5] Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on D-galactose-induced oxidative aging in mice
Zhao, Xin
Yi, Ruokun
Zhou, Xianrou
Mu, Jianfei
Long, Xingyao
Pan, Yanni
Song, Jia-Le
Park, Kun-Young
JOURNAL OF DAIRY SCIENCE, 2019, 102 (07) : 5899 - 5912
[6] Effect of soybean milk fermented withLactobacillus plantarumHFY01 isolated from yak yogurt on weight loss and lipid reduction in mice with obesity induced by a high-fat diet
Li, Chong
Liu, Huilin
Yang, Jiao
Mu, Jianfei
Wang, Ranran
Zhao, Xin
RSC ADVANCES, 2020, 10 (56) : 34276 - 34289
[7] Preventive effect of Lactobacillus plantarum YS1 isolated from naturally fermented yoghurt on carrageenan-induced thrombosis in mice
Wang, M. -w.
She, F.
Song, J.
Liu, Y. -q.
Long, X. -y.
Zhao, X.
Hong, H. -q.
ACTA ALIMENTARIA, 2023, 52 (04) : 623 - 635
[8] Effect of Lactobacillus plantarum KFY02 isolated from naturally fermented yogurt on the weight loss in mice with high-fat diet-induced obesity via PPAR-α/γ signaling pathway
Mu, Jianfei
Zhang, Jing
Zhou, Xianrong
Zalan, Zsolt
Hegyi, Ferenc
Takacs, Krisztina
Ibrahim, Amel
Awad, Sameh
Wu, Yun
Zhao, Xin
Du, Muying
JOURNAL OF FUNCTIONAL FOODS, 2020, 75

← 1 →