Computational Models for Ocular Drug Repurposing of a Ribosomal S6 Kinase Inhibitor (RSKi) in Treatment of Retinal Degenerative Diseases

被引：0

作者：

Mikayelyan, Lilit ^{[1
]}

Terneus, Marcus ^{[2
]}

Bramhall, Jessica ^{[2
]}

Bell, Sammy ^{[2
]}

Gukasyan, Hovhannes J. ^{[1
]}

机构：

[1] Univ Southern Calif, Mann Sch Pharm & Pharmaceut Sci, Los Angeles, CA USA

[2] Boehringer Ingelheim Pharmaceut Inc, External Alternat CMC Dev, Ridgefield, CT USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2024年 / 65卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

6128

引用

页数：2

共 33 条

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[2] The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
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Al Najjar, Afnan
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Ahmed, Rashid
Yalcin, Huseyin C.
Korashy, Hesham M.
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Riaz, Sadaf
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[3] The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice
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[4] A novel phosphatidylinositol-3-kinase inhibitor decreases activation of ribosomal protein S6 in psoriatic T cells
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Healy, E.
BRITISH JOURNAL OF DERMATOLOGY, 2014, 170 (04) : E29 - E29
[5] Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells
Deng, Lan
Jiang, Ling
Lin, Xianghua
Tseng, Kuo-Fu
Lu, Zhigang
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[6] Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)
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Haarer, Lisa
Schroder, Martin
Kudolo, Mark
Schwalm, Martin P.
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[7] Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
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Alton, Gordon R.
Richter, Daniel T.
Kath, John C.
Lingardo, Laura
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Hwang, Catherine
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[8] Enzastaurin, a protein kinase Cβ inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer
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[9] The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design
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[10] BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
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