Biological potential and therapeutic effectiveness with diverse signaling pathways of phyto-product chicoric acid: a comprehensive review with computational evidence

被引：0

作者：

Nazir, Muhammad Muzammil ^{[1
]}

Farzeen, Iqra ^{[1
]}

Zafar, Saima ^{[1
]}

Fatima, Sehrish ^{[1
]}

Zafar, Nimrah ^{[1
]}

Ashraf, Asma ^{[1
]}

Lebelo, Sogolo Lucky ^{[2
]}

机构：

[1] Govt Coll Univ, Dept Zool, Allama Iqbal Rd, Faisalabad 38000, Pakistan

[2] Univ South Africa, Dept Life & Consumer Sci, Coll Agr & Environm Sci, Pretoria, South Africa

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2025年

关键词：

Chicoric acid; Anti-cancer; Antidiabetics; Network pharmacology; Molecular docking; OXIDATIVE STRESS; CICHORIC ACID; METABOLISM; EXTRACT; CELLS; SUPPLEMENTATION; PHARMACOLOGY; LYMPHOCYTES; BIOACTIVITY; MECHANISMS;

D O I：

10.1007/s00210-025-03931-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chicoric acid (CA), a polyphenolic compound found in chicory (Cichorium intybus), shows potential for the management of a number of diseases due to its antioxidant, anticancer, anti-inflammatory, and insulin-sensitizing properties. Chicory, a perennial member of Asteraceae family, is undoubtedly an underestimated vegetable. Currently, its primary usage is concentrated in India, Greece, Italy, and Poland. This review will concentrate on the potential of chicoric acid in different diseases through a study of the literature and in silico research. A comprehensive search of the literature was conducted using specialized and dedicated search engines. Chicoric acid has an impact on several disease types reported in vitro and in vivo. Chicoric acid has surfaced as a promising neuroprotective agent, anticancer, anti-inflammatory, antidiabetics, and antimicrobial exhibiting a broad range of actions that contribute to health and function. Bioactive compound effects on diseases are examined using network pharmacology (ADME, networking, and docking). KEGG analysis and gene ontology demonstrated that chicoric acid works by interfering with many immune system and cancer pathways. Chicoric acid had the best match with receptor proteins 1PXX and 2YCF, which suited the chemical chicoric acid best, with docking scores of - 8.46 and - 9.4, respectively. To sum up, chicoric acid is a new molecule in the medication development process.

引用

页数：28