Chromones from Saposhnikovia divaricata and their inhibition of IL-1/3-induced proliferative activity in SW982 cells

Nine previously undescribed chromones, named sadivamones O-W (1-9), and five known analogues (10-14), were isolated from the roots of Saposhnikovia divaricata (Turcz.) Schischk. The detailed structural analysis of each compound was finalized by a variety of methods including NMR (1D and 2D), mass spectrometry (HR-ESI-MS) spectroscopic data, and sugar hydrolysis. The absolute configurations of compounds (4-5) were determined by CD. Moreover, compounds 1-14 were evaluated for their inhibition of IL-1/3-induced proliferative activity in SW982 cells. The results demonstrated that compounds 2-4 and 11-12 exhibited notable inhibitory effects on IL1/3-induced proliferation in a concentration-dependent manner, with the most pronounced inhibition observed at a concentration of 20 mu M.