Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation

被引：0
|
作者：
Wang Yao [2 ]
Dong-Ming Hua [1 ]
Ying-Ru Zhang [1 ]
Yi-Yang Zhao [1 ]
Ying Feng [2 ]
Zhao-Zhou Zhang [2 ]
Zhong-Ya Ni [1 ]
Hai-dong Guo [2 ]
Yun-Feng Guan [1 ]
Yan Wang [1 ]
机构：
[1] Shuguang Hospital,Department of Medical Oncology, Pudong New Area
[2] Shanghai University of Traditional Chinese Medicine,Academy of Integrative Medicine
[3] Shanghai University of Traditional Chinese Medicine,undefined
来源：
BMC Complementary Medicine and Therapies | / 25卷 / 1期
关键词：
Chronic stress; Colorectal cancer; Network pharmacology; IL-6/JAK2/STAT3; Glycolysis; Xiao-Chai-Hu-Tang;
D O I：
10.1186/s12906-025-04860-8
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 4 条
  • [1] Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang
    Jin, Jingyun
    Chen, Bin
    Zhan, Xiangyang
    Zhou, Zhiyi
    Liu, Hui
    Dong, Yun
    PLOS ONE, 2021, 16 (06):
  • [2] Xiao-Chai-Hu-Tang Ameliorates Depressive Symptoms via Modulating Neuro-Endocrine Network in Chronic Unpredictable Mild Stress-Induced Mice
    Feng, Ying
    Wang, Wenkai
    Zhang, Yingru
    Feng, Yuanyuan
    Zhao, Yiyang
    Zhang, Zhaozhou
    Wang, Yan
    CNS NEUROSCIENCE & THERAPEUTICS, 2025, 31 (02)
  • [3] Molecular mechanisms of the Guizhi decoction on osteoarthritis based on an integrated network pharmacology and RNA sequencing approach with experimental validation
    Chen, Yan
    Xue, Yan
    Wang, Xuezong
    Jiang, Ding
    Xu, Qinguang
    Wang, Lin
    Zheng, Yuxin
    Shi, Ying
    Cao, Yuelong
    FRONTIERS IN GENETICS, 2023, 14
  • [4] Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin against colon cancer: An integrated approach based on network pharmacology analysis coupled with experimental validation and molecular docking
    Hu, Yu
    Zhai, Wenjuan
    Tan, Duanling
    Chen, Haipeng
    Zhang, Guiyu
    Tan, Xuanjing
    Zheng, Yuting
    Gao, Wenhui
    Wei, Yijie
    Wu, Jinjun
    Yang, Xin
    FRONTIERS IN PHARMACOLOGY, 2023, 14
1