Design and cohort characteristics of TRACK, a prospective study of hyperkalaemia management decision-making

被引:0
|
作者
Hsia, Judith [1 ]
Shivappa, Nitin [2 ]
Bakhai, Ameet [3 ]
Bover, Jordi [4 ]
Butler, Javed [5 ,6 ]
Ferraro, Pietro Manuel [7 ]
Fried, Linda [8 ]
Schneider, Markus P. [9 ]
Tangri, Navdeep [10 ]
Winkelmayer, Wolfgang C. [11 ]
Bishop, Meredith [12 ]
Chen, Hungta [2 ]
Sundin, Anna-Karin [13 ]
Bonaca, Marc P. [1 ]
机构
[1] Univ Colorado, CPC Clin Res, Aurora, CO 80309 USA
[2] AstraZeneca, Wilmington, DE USA
[3] Royal Free NHS Hosp, London, England
[4] Hosp Badalona Germans Trias & Pujol, Badalona, Spain
[5] Baylor Scott & White Res Inst, Dallas, TX USA
[6] Univ Mississippi, Jackson, MI USA
[7] Univ Verona, Verona, Italy
[8] Pittsburgh Healthcare Syst, Pittsburgh, PA USA
[9] Univ Erlangen Nurnberg, Erlangen, Germany
[10] Univ Manitoba, Winnipeg, MB, Canada
[11] Baylor Coll Med, Houston, TX USA
[12] AstraZeneca, Gaithersburg, MD USA
[13] AstraZeneca, Gothenburg, Sweden
关键词
chronic kidney disease; heart failure; hyperkalaemia management; RAASi; real-world evidence;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background. Guideline-recommended hyperkalaemia management includes dietary potassium (K+) restriction, bicarbonate correction, diuretics and K+ binders with dose reduction of renin-angiotensin-aldosterone system inhibitors as a last resort. The extent to which these recommendations are implemented is uncertain, as real-world data on hyperkalaemia management are limited. The Tracking Treatment Pathways in Adult Patients with Hyperkalemia ( TRACK) study is a multinational, prospective, longitudinal study that is being conducted to address this knowledge gap. We report the design and baseline cohort characteristics of this real-world study of hyperkalaemia management decision-making. Methods. This study enrolled participants within 21 days of an episode of hyperkalaemia in four European countries ( UK, Spain, Germany, Italy) and the USA. During the 12-month follow up, data collected will include participant and healthcare provider characteristics ( specialty and practice setting) , hyperkalaemia treatment objectives and strategies, rationale for management decisions and indicators of response and patient-reported perceptions of their hyperkalaemia treatment. Results. The enrolled cohort includes 1330 participants, mean age 68 years, of whom 31% were women. At baseline, 6% reported heart failure, 55% chronic kidney disease, 29% both and 9% neither. Most participants ( 57%) were taking an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or angiotensin receptor/neprilysin inhibitor at baseline. Mineralocorticoid receptor antagonist use was lower ( 14%) . Conclusions. The prospective TRACK study will shed light on practitioners' hyperkalaemia management decision-making and assess the impact of their decisions on hyperkalaemia recurrence. Understanding practitioners' underlying thought processes will facilitate efforts to improve hyperkalaemia management.
引用
收藏
页数:9
相关论文
共 50 条
  • [11] Decision-making preferences and regret in rectal cancer patients undergoing restorative proctectomy: A prospective cohort study
    Joshua, Temitope G.
    Robitaille, Stephan
    Paradis, Tiffany
    Maalouf, Michael F.
    Feldman, Liane S.
    Fiore Jr, Julio F.
    Liberman, Sender
    Lee, Lawrence
    SURGERY, 2024, 176 (04) : 1065 - 1071
  • [12] Association of shared decision-making cessation model and adult smoking cessation rate: A prospective cohort study
    Chen, Kuan-Lun
    Hsu, Yun-Chen
    Li, Yi-Hsuan
    Guo, Fei-Ran
    Tsai, Jaw-Shiun
    Cheng, Shao-Yi
    Huang, Hsien-Liang
    TOBACCO INDUCED DISEASES, 2025, 23
  • [13] Risky decision-making in children with and without ADHD: A prospective study
    Humphreys, Kathryn L.
    Tottenham, Nim
    Lee, Steve S.
    CHILD NEUROPSYCHOLOGY, 2018, 24 (02) : 261 - 276
  • [14] MANAGEMENT AND ETHICAL DECISION-MAKING
    ROBISON, WL
    JOURNAL OF BUSINESS ETHICS, 1984, 3 (04) : 287 - 291
  • [15] MANAGEMENT FOR DECISION-MAKING - DISCUSSION
    NIELSON, J
    JOURNAL OF FARM ECONOMICS, 1964, 46 (05): : 1186 - 1190
  • [16] IDEALISM AND MANAGEMENT DECISION-MAKING
    RICE, GH
    JOURNAL OF GENERAL MANAGEMENT, 1980, 5 (02) : 14 - 21
  • [17] A prospective study of shared decision-making in brain tumor surgery
    Severina Leu
    Julian Cahill
    Paul L. Grundy
    Acta Neurochirurgica, 2023, 165 : 15 - 25
  • [18] A prospective study of shared decision-making in brain tumor surgery
    Leu, Severina
    Cahill, Julian
    Grundy, Paul L.
    ACTA NEUROCHIRURGICA, 2023, 165 (01) : 15 - 25
  • [19] CONFERENCE FOR DECISION-MAKING IN MANAGEMENT
    不详
    SVENSK PAPPERSTIDNING-NORDISK CELLULOSA, 1979, 82 (06): : 155 - 160
  • [20] MAINTENANCE MANAGEMENT DECISION-MAKING
    PINTELON, LM
    GELDERS, LF
    EUROPEAN JOURNAL OF OPERATIONAL RESEARCH, 1992, 58 (03) : 301 - 317