Phage therapy could be key to conquering persistent bacterial lung infections in children

被引：0

作者：

Aye Mya Sithu Shein ^{[1
]}

Parichart Hongsing ^{[2
]}

Aisha Khatib ^{[3
]}

Phatthranit Phattharapornjaroen ^{[4
]}

Kazuhiko Miyanaga ^{[5
]}

Longzhu Cui ^{[6
]}

Kenji Shibuya ^{[7
]}

Mohan Amarasiri ^{[8
]}

Peter N. Monk ^{[8
]}

Anthony Kicic ^{[9
]}

Tanittha Chatsuwan ^{[10
]}

Paul G. Higgins ^{[11
]}

Shuichi Abe ^{[12
]}

Dhammika Leshan Wannigama ^{[13
]}

机构：

[1] Thai Red Cross Society,Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital

[2] Chulalongkorn University,Center of Excellence in Antimicrobial Resistance and Stewardship Research, Faculty of Medicine

[3] Mae Fah Luang University Hospital,School of Integrative Medicine

[4] Mae Fah Luang University,Department of Family & Community Medicine

[5] University of Toronto,Faculty of Health Science Technology

[6] Chulabhorn Royal Academy,HRH Princess Chulabhorn Disaster and Emergency Medicine Center

[7] Chulabhorn Royal Academy,Division of Bacteriology, School of Medicine

[8] Jichi Medical University,Department of Civil and Environmental Engineering, Graduate School of Engineering

[9] Tokyo Foundation for Policy Research,Department of Infection, Immunity & Cardiovascular Disease

[10] Tohoku University,Wal

[11] University of Sheffield Medical School,yan Respiratory Research Centre, Telethon Kids Institute

[12] University of Western Australia,Centre for Cell Therapy and Regenerative Medicine, Medical School

[13] The University of Western Australia,Department of Respiratory and Sleep Medicine

[14] Perth Children’s Hospital,School of Population Health

[15] Curtin University,Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne

[16] University of Cologne,German Centre for Infection Research

[17] Partner site Bonn-Cologne,Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne

[18] University of Cologne,Department of Infectious Diseases and Infection Control

[19] Yamagata Prefectural Central Hospital,School of Medicine, Faculty of Health and Medical Sciences

[20] The University of Western Australia,Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries

[21] The University of Sheffield,Pathogen Hunter’s Research Team, Department of Infectious Diseases and Infection Control

[22] Yamagata Prefectural Central Hospital,undefined

来源：

npj Antimicrobials and Resistance | / 2卷 / 1期

关键词：

D O I：

10.1038/s44259-024-00045-4

中图分类号：

学科分类号：

摘要：

Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demonstrating significant therapeutic benefits through various administration routes. Ongoing trials are evaluating its safety and effectiveness against different pathogens. Advancing phage therapy through systematic studies and international collaboration could provide a viable alternative to traditional antibiotics for persistent infections.

引用

共 50 条

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