Application of injectable platelet-rich fibrin (I-PRF) after posterior tooth removal surgery: a systematic review

Injectable platelet-rich fibrin (I-PRF) is primarily found in liquid form and plays a role in accelerating vascularization and aiding wound healing. To carry out a critical analysis of the therapeutic potential of injectable platelet-rich fibrin (I-PRF) in the postoperative management of these surgeries. The systematic review protocol for this study included start and end dates, research question, databases, PICO structure, search strategy, inclusion/exclusion criteria, types of studies, measures of effect, screening methods, data extraction/analysis and risk of bias assessment tools. Registered with PROSPERO (CRD42024537367), it guaranteed transparency and quality. Searches were carried out on the PubMed, Scopus, Embase, Wiley Online Library and Web of Science databases. Results: The systematic search in the databases identified 532 studies. After removing duplicates with Rayyan (c) software, 480 documents remained, of which 15 met the inclusion criteria. After evaluation following the review protocol, 5 studies were considered highly relevant and included in the systematic review. The results indicated not only uncomplicated healing and adequate osseointegration, but also a significant improvement in comfort parameters and post-operative recovery. It was observed that the application of I-PRF accelerated the healing process, reduced pain and edema, and improved soft and hard tissue regeneration.