Relationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study

被引：0

作者：

Yu, Xinyang ^{[1
]}

Zhang, Zuo ^{[1
]}

Herle, Moritz ^{[1
]}

Banaschewski, Tobias ^{[2
]}

Barker, Gareth J. ^{[3
]}

Bokde, Arun L. W. ^{[4
,5
]}

Flor, Herta ^{[6
,7
]}

Grigis, Antoine ^{[8
]}

Garavan, Hugh ^{[9
,10
]}

Gowland, Penny ^{[11
]}

Heinz, Andreas ^{[12
,13
,14
,15
]}

Bruehl, Ruediger ^{[16
]}

Martinot, Jean-Luc ^{[17
]}

Martinot, Marie-Laure Paillere ^{[17
,18
]}

Artiges, Eric ^{[17
]}

Nees, Frauke ^{[2
,6
,19
]}

Orfanos, Dimitri Papadopoulos ^{[8
]}

Lemaitre, Herve ^{[8
,20
]}

Paus, Tomas ^{[21
,22
,23
]}

Poustka, Luise ^{[24
]}

Hohmann, Sarah ^{[25
]}

Holz, Nathalie ^{[2
]}

Baeuchl, Christian ^{[26
]}

Smolka, Michael N. ^{[26
]}

Vaidya, Nilakshi ^{[27
]}

Walter, Henrik ^{[12
,13
,14
,15
]}

Whelan, Robert ^{[28
,29
]}

Schmidt, Ulrike ^{[30
,31
]}

Schumann, Gunter ^{[32
,33
]}

Desrivieres, Sylvane ^{[1
]}

IMAGEN Consortium, Uli

Bromberg, Uli ^{[34
]}

Buechel, Christian ^{[34
]}

Ittermann, Bernd ^{[16
]}

Froehner, Juliane H. ^{[35
,36
]}

机构：

[1] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

[2] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany

[3] Kings Coll London, Dept Neuroimaging, Inst Psychiat Psychol & Neurosci, London, England

[4] Trinity Coll Dublin, Sch Med, Trinity Coll Inst Neurosci, Dublin 2, Ireland

[5] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland

[6] Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany

[7] Univ Mannheim, Sch Social Sci, Dept Psychol, Mannheim, Germany

[8] Univ Paris Saclay, CNRS, NeuroPSI, Gif Sur Yvette, France

[9] Univ Vermont, Dept Psychiat, Burlington, VT USA

[10] Univ Vermont, Dept Psychol, Burlington, VT USA

[11] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Nottingham, England

[12] Charite Univ Med Berlin, Campus Charite Mitte, Berlin, Germany

[13] Free Univ Berlin, Campus Charite Mitte, Berlin, Germany

[14] Humboldt Univ, Campus Charite Mitte, Berlin, Germany

[15] Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Berlin, Germany

[16] Phys Tech Bundesanstalt PTB, Berlin, Germany

[17] Univ Paris Saclay, Ecole Normale Super Paris Saclay, Ctr Borelli, CNRS,UMR9010,INSERM U1299 Dev Trajectories & Psych, Gif Sur Yvette, France

[18] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Child & Adolescent Psychiat, Paris, France

[19] Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Med Psychol & Med Sociol, Kiel, Germany

[20] Univ Bordeaux, CNRS, UMR 5293, Inst Malad Neurodegenerat,CEA, Bordeaux, France

[21] Univ Montreal, Ctr Hosp Univ Sainte Justine, Montreal, PQ, Canada

[22] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ, Canada

[23] Univ Montreal, Ctr Hosp Univ St Justine, Montreal, PQ, Canada

[24] Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Gottingen, Germany

[25] Univ Med Ctr Hamburg Eppendorf, Dept Child & Adolescent Psychiat, Psychotherapy & Psychosomat, Hamburg, Germany

[26] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Dresden, Germany

[27] Charite Univ Med Berlin, Ctr Populat Neurosci & Stratified Med PONS, Dept Psychiat Psychotherapy, Berlin, Germany

[28] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland

[29] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

[30] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Res Eating & Weight Disorders, Dept Psychol Med, London, England

[31] South London & Maudsley NHS Fdn Trust, London, England

[32] Charite Univ Med Berlin, Ctr Populat Neurosci & Stratified Med PONS, Dept Psychiat & Neurosci, Berlin, Germany

[33] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence IST, Ctr Populat Neurosci & Precis Med, Shanghai, Peoples R China

[34] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

[35] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[36] Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

来源：

NATURE MENTAL HEALTH | 2025年 / 3卷 / 01期

基金：

英国医学研究理事会; 爱尔兰科学基金会; 欧洲研究理事会; 英国科研创新办公室; 美国国家卫生研究院;

关键词：

BODY-MASS INDEX; QUALITY-OF-LIFE; ANOREXIA-NERVOSA; DISORDER; MEN; QUESTIONNAIRE; MORTALITY; FAMILY; ONSET;

D O I：

10.1038/s44220-024-00354-7

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Unhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional and behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from the longitudinal IMAGEN adolescent cohort, we investigated associations between eating behaviors, genetic predispositions for high body mass index (BMI) using polygenic scores (PGSs), and trajectories (ages 14-23 years) of ED-related psychopathology and brain maturation. Clustering analyses at age 23 years (N = 996) identified 3 eating groups: restrictive, emotional/uncontrolled and healthy eaters. BMI PGS, trajectories of ED symptoms, internalizing and externalizing problems, and brain maturation distinguished these groups. Decreasing volumes and thickness in several brain regions were less pronounced in restrictive and emotional/uncontrolled eaters. Smaller cerebellar volume reductions uniquely mediated the effects of BMI PGS on restrictive eating, whereas smaller volumetric reductions across multiple brain regions mediated the relationship between elevated externalizing problems and emotional/uncontrolled eating, independently of BMI. These findings shed light on distinct contributions of genetic risk, protracted brain maturation and behaviors in ED symptomatology.

引用

页码：58 / 70

页数：18

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