Unveiling the complexity of G protein-coupled receptor heteromers: advances in live cell imaging technologies and biochemical methods

被引：0
|
作者：
Hyunbin Kim [1 ]
Huimin Lee [2 ]
Jihye Seong [2 ]
机构：
[1] Neuroscience Research Institute,Department of Pharmacology
[2] Seoul National University College of Medicine,Department of Biomedical Sciences
[3] Seoul National University College of Medicine,undefined
[4] Seoul National University College of Medicine,undefined
[5] Seoul National University Bundang Hospital,undefined
来源：
Med-X | / 2卷 / 1期
关键词：
GPCR; Heteromer; Fluorescent biosensor; Circularly permuted fluorescent protein; Functional crosstalk;
D O I：
10.1007/s44258-024-00029-z
中图分类号：
学科分类号：
摘要：
The discovery of G protein-coupled receptor (GPCR) heteromers has revealed a new level of complexity in their functional characteristics.This review explores a variety of methodologies and live cell imaging technologies for the investigation of physical interactions in GPCR heteromers and their functional alterations.Live cell imaging technologies such as fluorescent protein-based biosensors promise a deeper understanding of GPCR heteromers, urging a reassessment of their physiological importance and pharmacological relevance.
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