Recommendations to promote equity, diversity and inclusion in decentralized clinical trials

被引：1

作者：

Aiyegbusi, Olalekan Lee ^{[1
,2
,3
,4
,5
]}

Cruz Rivera, Samantha ^{[1
,5
]}

Kamudoni, Paul ^{[6
]}

Anderson, Nicola ^{[1
,2
,3
,7
]}

Collis, Philip ^{[1
]}

Denniston, Alastair K. ^{[2
,5
,7
]}

Harding, Rosie ^{[8
]}

Hughes, Sarah E. ^{[1
,2
,3
,4
]}

Khunti, Kamlesh ^{[9
,10
]}

Kotecha, Dipak ^{[2
,11
,12
]}

Krumholz, Harlan ^{[13
]}

Liu, Xiaoxuan ^{[2
,5
,7
]}

Mcmullan, Christel ^{[1
,4
]}

Molony-Oates, Barbara ^{[14
]}

Monteiro, Joao ^{[15
]}

Myles, Puja ^{[16
]}

Rantell, Khadija Rerhou ^{[17
]}

Soltys, Katherine ^{[18
]}

Verdi, Ravinder ^{[1
]}

Wilson, Roger ^{[1
,19
]}

Calvert, Melanie J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Birmingham, Inst Appl Hlth Res, Coll Med & Dent Sci, Ctr Patient Reported Outcomes Res, Birmingham, England

[2] Univ Birmingham, Natl Inst Hlth & Care Res NIHR, Birmingham Biomed Res Ctr, Birmingham, England

[3] Univ Birmingham, Natl Inst Hlth & Care Res Appl Res Collaborat West, Birmingham, England

[4] Univ Birmingham, NIHR Blood & Transplant Res Unit BTRU, Precis Transplant & Cellular Therapeut, Birmingham, England

[5] Univ Birmingham, Birmingham Hlth Partners Ctr Regulatory Sci & Inno, Birmingham, England

[6] Merck, Darmstadt, Germany

[7] Univ Hosp Birmingham NHS Fdn Trust, Birmingham, England

[8] Univ Birmingham, Birmingham Law Sch, Birmingham, England

[9] Univ Leicester, Diabet Res Ctr, NIHR Appl Res Collaborat East Midlands, Leicester, England

[10] Univ Leicester, Diabet Res Ctr, Leicester, England

[11] Univ Birmingham, Inst Cardiovasc Sci, Birmingham, England

[12] Univ Hosp Birmingham NHS Fdn Trust, West Midlands NHS Secure Data Environm, Birmingham, England

[13] Yale Univ, Yale Sch Med, New Haven, CT USA

[14] Hlth Res Author, London, England

[15] New York Acad Med, New York, NY USA

[16] Med & Healthcare Prod Regulatory Agcy, Clin Practice Res Datalink, London, England

[17] Med & Healthcare Prod Regulatory Agcy, London, England

[18] Hlth Canada, Ottawa, ON, Canada

[19] Canc Res Advocacy Forum, London, England

来源：

NATURE MEDICINE | 2024年

关键词：

HEALTH-CARE RECORDS; OUTCOME ASSESSMENT; FRAMEWORK; ONCOLOGY; MODELS;

D O I：

10.1038/s41591-024-03323-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. Rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer and store electronic data. While some studies have demonstrated the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges that may create or worsen existing health inequalities and limit the generalizability of trial results. Here we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity and inclusion. Digitally enabled and decentralized clinical trials could enable large-scale recruitment of diverse participants-but careful consideration of the barriers faced by underserved groups will be crucial to their success.

引用

页码：3075 / 3084

页数：10

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