Characterization of a Novel Tn7-like Transposon Carrying blaDHA-1 in Providencia stuartii MF1 Isolated from Swine Wastewater

被引：0
|
作者：
Ou, Shijie [1 ,2 ]
Tian, Xinyi [2 ]
Zhang, Zhen [2 ]
Zhu, Lingjia [3 ]
Wang, Rong [2 ]
Cao, Guangxiang [1 ,2 ]
Fu, Jiafang [1 ,2 ]
Zhang, Peipei [1 ,2 ]
机构：
[1] Shandong First Med Univ, Dept Epidemiol, Affiliated Hosp 1, Jinan, Peoples R China
[2] Shandong First Med Univ & Shandong Acad Med Sci, Coll Biomed Sci, Jinan, Peoples R China
[3] Duke Kunshan Univ, Kunshan, Peoples R China
来源：
CURRENT MICROBIOLOGY | 2025年 / 82卷 / 01期
关键词：
RESISTANCE; BACTERIA; SEQUENCE; TN7;
D O I：
10.1007/s00284-024-03952-x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Providencia stuartii is an emerging pathogen that causes nosocomial infections. In this study, a multidrug-resistant strain P. stuartii MF1 was isolated from swine wastewater. Comprehensive analysis of whole genome sequencing revealed that dozens of antibiotic resistance genes were found in MF1. A novel transposon Tn6450M which has high sequence identity to Tn6450 and the plasmid-borne Tn6765 from Proteus mirabilis was identified in the genome of MF1. Tn6450M was determined to be stably inserted into a new attTn7 site in the P. stuartii MF1 genome and contains the third-generation cephalosporins resistance-associated genes blaDHA-1. Intergeneric transmission of Tn6450 variants poses risks for the spread of antibiotic resistance genes.
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页数：7
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