Comparing Kramer's rule with transcutaneous bilirubin vs. Kramer's rule only in reducing total serum bilirubin sampling among neonates with jaundice

被引：0

作者：

Lim, Xin-Jie ^{[1
]}

Ambigapathy, Subashini ^{[2
]}

Leong, E-Li ^{[1
]}

Marmuji, Lili Zuryani ^{[3
]}

Phan, Ai-Ping ^{[4
]}

Hamdan, Farah Aishah ^{[5
]}

Mithra, Sheela Mithra Nandi ^{[6
]}

Azmi, Nurul Idayu Mior ^{[7
]}

Devesahayam, Philip Rajan ^{[1
,8
]}

P. Nachiappan, Jeyaseelan ^{[9
]}

机构：

[1] Hosp Raja Permaisuri Bainun, Clin Res Ctr, Minist Hlth, Ipoh, Malaysia

[2] Minist Hlth, Buntong Primary Care Clin, Ipoh, Malaysia

[3] Minist Hlth, Gunung Rapat Primary Care Clin, Ipoh, Malaysia

[4] Minist Hlth, Batu Gajah Women & Children Hlth Clin, Ipoh, Malaysia

[5] Minist Hlth, Chemor Primary Care Clin, Ipoh, Malaysia

[6] Minist Hlth, Tanjung Rambutan Primary Care Clin, Ipoh, Malaysia

[7] Minist Hlth, Pengkalan Pegoh Women & Children Hlth Clin, Ipoh, Malaysia

[8] Taylors Univ, Subang Jaya, Selangor, Malaysia

[9] Univ Kuala Lumpur UniKL RCMP, Royal Coll Med Perak, Fac Med, Ipoh, Malaysia

来源：

BMC PEDIATRICS | 2025年 / 25卷 / 01期

关键词：

Neonatal jaundice; Screening; Kramer's Rule; Transcutaneous bilirubin; Total serum bilirubin; HYPERBILIRUBINEMIA;

D O I：

10.1186/s12887-025-05423-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundIn the Malaysian primary healthcare setting, neonatal jaundice (NNJ) screening uses either Kramer's Rule (KR), a visual assessment, or a combination with non-invasive transcutaneous bilirubin (TcB). However, data on the quantification of the need for total serum bilirubin (TSB) sampling between these approaches are limited. This study aimed to compare the frequency of blood draws required between the two cohorts, alongside investigating disparities in phototherapy initiation and severe hyperbilirubinemia occurrences.MethodsThis multicentre retrospective cohort study enrolled neonates from six primary healthcare clinics, with three using KR plus TcB and three using KR only for NNJ screening. Neonates with a gestational age of >= 35 weeks and without prior phototherapy or exchange transfusion for hyperbilirubinemia were included in the study until reaching either day 10 of life or hospitalization for any reason, defining the study endpoint. The minimum sample size required was 379 neonates in each cohort. Generalized Poisson regression was used to compare the number of blood draws required for TSB sampling between the two cohorts.ResultsOf 765 neonates included, the cohort using KR alongside TcB showed a 74% reduction in blood draw risk compared to KR alone cohort (IRR 0.26, 95% CI 0.23-0.39). There were no significant differences between cohorts in phototherapy initiation (25.5% vs. 24.4%), severe hyperbilirubinemia occurrence (0.0% vs. 0.0%) or rapid bilirubin level rise (0.3% vs. 0.8%).ConclusionIncorporating TcB alongside KR for NNJ screening significantly reduces the need for TSB sampling without causing an escalation in phototherapy initiation or severe hyperbilirubinemia occurrences, suggesting the potential to optimize NNJ management in the local primary care setting.

引用

页数：8