Features of Metabolism and Its Regulation in the Dynamics of Experimental Models of Metabolic Disorders

被引：0

作者：

Shestopalov, A. V. ^{[2
,3
,4
]}

Krolenko, E. V. ^{[3
]}

Nedorubov, A. A. ^{[1
]}

Borisenko, O. V. ^{[3
]}

Popruga, K. E. ^{[5
]}

Makarov, V. V. ^{[4
]}

Yudin, S. M. ^{[5
]}

Gaponov, A. M. ^{[1
]}

Rumyantsev, S. A. ^{[1
,3
,4
]}

机构：

[1] Ctr Digital & Translat Biomed LLC, Ctr Mol Hlth, Moscow, Russia

[2] Minist Hlth Russian Federat, Dmitry Rogachev Natl Med Res Ctr Pediat Hematol On, Moscow, Russia

[3] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia

[4] Minist Hlth Russian Federat, Natl Med Res Ctr Endocrinol, Moscow, Russia

[5] Fed Med Biol Agcy, Ctr Strateg Planning Management Biomed Hlth Risks, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 178卷 / 02期

关键词：

NOD; C57BL/6; db/db; obesity; diabetes mellitus; DB/DB MICE; LEPTIN; INSULIN; PLASMA;

D O I：

10.1007/s10517-025-06321-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in the lipid and carbohydrate metabolism, adipokines, and growth factors during the development of metabolic disorders were studied in three mouse models: C57BL/6 (alimentary obesity), db/db (leptin-resistant obesity), and NOD (diabetes mellitus) lines. In the group of alimentary obesity, moderate fatty infiltration of the liver and hypertrophy of the adipose tissue, hyperglycemia, and increased concentrations of adiponectin, transforming growth factor beta 1 (TGF-beta 1), leptin, and cholesterol were detected. In the group of leptin-resistant obesity, multiple pathological changes in tissues, severe hyperglycemia and hyperleptinemia, hyperinsulinemia, and reduced concentrations of triglycerides, adiponectin, myostatin, and TGF-beta 1 were detected. In NOD mice, reduced number of insulin-positive beta cells, hyperinsulinemia, and a decrease in adiponectin, TGF-beta 1, leptin, and myostatin concentrations were detected.

引用

页码：280 / 286

页数：7

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